DegronMD

Uniprot ID: O95402

Source protein: Mediator of RNA polymerase II transcription subunit 26

Source gene: MED26

Class: LIG_APCC_ABBA_1

Location: 582:587

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6791

ASA_SCORE: 66.6833

COIL: 0.7667

CONS_SCORE: 0.5892

DSS_SCORE: 0.1375

HELIX: 0.0495

FCONS_SCORE: 0.8262

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W576C	TCGA-B5-A1MX	UCEC	TCGA	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.W576C	DO41999	UCEC	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.D588N	TCGA-DK-A3IL	BLCA	TCGA	LDPHGD	LIG_APCC_ABBA_1	0.3056
p.D588N	DO555	BLCA	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.3056
p.D583N	DO230334	COCA	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.5821
p.N572K	DO228948	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.0556
p.P584Q	DO229019	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.7035
p.T577K	DO229041	LICA	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.1944
p.R590H	DO29760	OV	ICGC	LDPHGD	LIG_APCC_ABBA_1	0.25
p.I593V	SIDM00043	Head and Neck Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.I593V	SIDM01149	Small Cell Lung Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.I593V	SIDM00794	Other Solid Cancers	GDSC	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.I593V	SIDM00059	Ovarian Carcinoma	GDSC	LDPHGD	LIG_APCC_ABBA_1	0.1667
p.I593V	SIDM01696	Mesothelioma	GDSC	LDPHGD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95402	Mediator of RNA polymerase II transcription subunit 26	LIG_APCC_ABBA_1	582:587	LDPHGD	APC,CDC20,FZR1	0.6791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons