DegronMD

Uniprot ID: Q8IXK0

Source protein: Polyhomeotic-like protein 2

Source gene: PHC2

Class: DEG_SCF_FBW7_1

Location: 261:268

E3 ligase: FBXW7

DEGRON score: 0.8292

ASA_SCORE: 90.925

COIL: 0.932

CONS_SCORE: 0.4239

DSS_SCORE: 0.82

HELIX: 0.0273

FCONS_SCORE: 0.9492

RIG_SCORE: 0.606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q260P	TCGA-14-0866	GBM	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	0.3056
p.Q260P	DO11878	GBM	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.3056
p.P263S	TCGA-90-A4ED	LUSC	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	0.5641
p.P261L	TCGA-MT-A67D	HNSC	TCGA	PLPTPAQS	DEG_SCF_FBW7_1	0.6471
p.E262Q	DO51893	BLCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.6744
p.V277L	DO4287	BRCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.0833
p.G277D	DO8018	COAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.0833
p.R262C	DO8119	COAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.8301
p.R262C	DO228138	PBCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.8301
p.R262C	DO42280	UCEC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.8301
p.V277M	DO234389	ESAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.0833
p.A270V	DO233115	GACA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.2778
p.C271Y	DO17188	KIRC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.25
p.P272T	DO228978	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.2222
p.R262H	DO50849	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.8244
p.R262H	DO231645	LINC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.8244
p.R262H	22RV1	prostate	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	0.8244
p.D263G	DO44832	LICA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.7198
p.V277A	DO45494	LUSC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.0833
p.V277A	SNU-1040	large_intestine	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	0.0833
p.P272S	DO51776	STAD	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.2222
p.A251S	DO229253	THCA	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.0556
p.P261S	DO42472	UCEC	ICGC	PLPTPAQS	DEG_SCF_FBW7_1	0.6752
p.G278C	ACH-002026	Endometrial/Uterine Cancer	CCLE	PLPTPAQS	DEG_SCF_FBW7_1	0.0556
p.Y275H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLPTPAQS	DEG_SCF_FBW7_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXK0	Polyhomeotic-like protein 2	DEG_SCF_FBW7_1	261:268	PLPTPAQS	FBXW7	0.8292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons