DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 922:926

E3 ligase: SPOP

DEGRON score: 0.9792

ASA_SCORE: 87.8

COIL: 0.8662

CONS_SCORE: 0

DSS_SCORE: 0.4596

HELIX: 0.0152

FCONS_SCORE: 0

RIG_SCORE: 0.6727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L916V	TCGA-18-3416	LUSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1667
p.L916V	DO26423	LUSC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1667
p.S925I	TCGA-B0-4706	KIRC	TCGA	ATSST	DEG_SPOP_SBC_1	0.7341
p.S925I	DO20565	KIRC	ICGC	ATSST	DEG_SPOP_SBC_1	0.7341
p.S914F	TCGA-CV-7568	HNSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1111
p.S914F	DO14160	HNSC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1111
p.S912Y	TCGA-DF-A2KU	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.S912Y	DO223286	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.E919K	TCGA-EB-A4XL	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.25
p.E919K	DO47401	SKCM	ICGC	ATSST	DEG_SPOP_SBC_1	0.25
p.A935V	TCGA-EE-A2GP	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.0833
p.A935V	DO37422	SKCM	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.S913P	TCGA-EO-A3KX	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0833
p.S913P	DO219774	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.0833
p.S927L	TCGA-GF-A6C9	SKCM	TCGA	ATSST	DEG_SPOP_SBC_1	0.75
p.S927L	DO51254	SKCM	ICGC	ATSST	DEG_SPOP_SBC_1	0.75
p.S924R	TCGA-L5-A4OI	ESCA	TCGA	ATSST	DEG_SPOP_SBC_1	0.7427
p.S912F	DO222653	MELA	ICGC	ATSST	DEG_SPOP_SBC_1	0.0556
p.R921T	SIDM00377	Other Sarcomas	GDSC	ATSST	DEG_SPOP_SBC_1	0.3056
p.R921T	SKN	soft_tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	0.3056
p.T932A	SIDM00197	Ewing's Sarcoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.6111
p.T932A	EW-18	bone	COSMIC	ATSST	DEG_SPOP_SBC_1	0.6111
p.N930H	SIDM00534	Colorectal Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.N930H	ACH-000986	Colon/Colorectal Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	0.2222
p.N930H	HT-115	large_intestine	COSMIC	ATSST	DEG_SPOP_SBC_1	0.2222
p.L936P	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.0556
p.L936P	ACH-000158	Lymphoma	CCLE	ATSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of ATSST