DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4375:4379

E3 ligase: SPOP

DEGRON score: 0.8031

ASA_SCORE: 89.32

COIL: 0.9414

CONS_SCORE: 0.3376

DSS_SCORE: 0.6337

HELIX: 0.016

FCONS_SCORE: -0.0011

RIG_SCORE: 0.6723

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4376S	TCGA-85-A5B5	LUSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.6005
p.T4376S	TCGA-BS-A0V8	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.6005
p.V4365L	TCGA-98-A538	LUSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.0556
p.A4375T	TCGA-AB-2931	LAML	TCGA	ATSST	DEG_SPOP_SBC_1	0.7139
p.A4375T	TCGA-AP-A056	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.7139
p.S4377R	TCGA-B5-A1MR	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	0.7427
p.T4379P	TCGA-BR-A4J8	STAD	TCGA	ATSST	DEG_SPOP_SBC_1	0.7031
p.T4368M	TCGA-CN-6021	HNSC	TCGA	ATSST	DEG_SPOP_SBC_1	0.1389
p.T4368M	SIDM00499	Prostate Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1389
p.T4368M	22RV1	prostate	COSMIC	ATSST	DEG_SPOP_SBC_1	0.1389
p.T4368K	TCGA-EL-A3ZR	THCA	TCGA	ATSST	DEG_SPOP_SBC_1	0.1389
p.T4375M	DO6472	CLLE	ICGC	ATSST	DEG_SPOP_SBC_1	0.7423
p.T4371M	DO15847	HNSC	ICGC	ATSST	DEG_SPOP_SBC_1	0.2222
p.A4378T	DO22074	LAML	ICGC	ATSST	DEG_SPOP_SBC_1	0.7139
p.A4378T	DO35442	PACA	ICGC	ATSST	DEG_SPOP_SBC_1	0.7139
p.A4378T	DO43971	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.7139
p.T4379S	DO50102	LUSC	ICGC	ATSST	DEG_SPOP_SBC_1	0.6005
p.T4379S	DO42240	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.6005
p.V4368L	DO219177	LUSC	ICGC	ATSST	DEG_SPOP_SBC_1	0.1389
p.T4371K	DO39018	THCA	ICGC	ATSST	DEG_SPOP_SBC_1	0.2222
p.S4380R	DO41758	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	0.3056
p.A4370T	SIDM00072	Non-Cancerous	GDSC	ATSST	DEG_SPOP_SBC_1	0.1944
p.A4370T	SIDM00013	Melanoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1944
p.A4370T	SIDM00049	Colorectal Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.1944
p.T4371A	SIDM00330	Neuroblastoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.T4371A	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.T4371A	SIDM00879	Breast Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.T4371A	SIDM00655	Other Solid Cancers	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.T4371A	SIDM01187	Breast Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	0.2222
p.T4372S	SIDM00917	Acute Myeloid Leukemia	GDSC	ATSST	DEG_SPOP_SBC_1	0.25
p.T4372S	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	0.25
p.T4379R	NCI-H1876	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	0.7876

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SPOP_SBC_1	742:746	ATSST	SPOP	0.8838	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	667:671	ATSST	SPOP	0.9758	More...
Q14684	Ribosomal RNA processing protein 1 homolog B	DEG_SPOP_SBC_1	450:454	ATSST	SPOP	0.9979	More...
Q14980	Nuclear mitotic apparatus protein 1	DEG_SPOP_SBC_1	1850:1854	ATSST	SPOP	0.9984	More...
Q15858	Sodium channel protein type 9 subunit alpha	DEG_SPOP_SBC_1	1948:1952	ATSST	SPOP	0.9534	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	545:549	ATSST	SPOP	0.9791	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3201:3205	ATSST	SPOP	0.7972	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	DEG_SPOP_SBC_1	508:512	ATSST	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6355:6359	ATSST	SPOP	0.9855	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6643:6647	ATSST	SPOP	0.9478	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6733:6737	ATSST	SPOP	0.9478	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	16:20	ATSST	SPOP	0.8574	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	922:926	ATSST	SPOP	0.9792	More...
Q9C0G6	Dynein axonemal heavy chain 6	DEG_SPOP_SBC_1	116:120	ATSST	SPOP	0.9908	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4375:4379	ATSST	SPOP	0.8031	More...
Q9NP66	High mobility group protein 20A	DEG_SPOP_SBC_1	42:46	ATSST	SPOP	0.9289	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	2451:2455	ATSST	SPOP	0.9815	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	431:435	ATSST	SPOP	0.9583	More...
Q86XN7	Proline and serine-rich protein 1	DEG_SPOP_SBC_1	727:731	ATSST	SPOP	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of ATSST