DegronMD - P42566(EPS15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R740H	TCGA-06-5858	GBM	TCGA	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2778
p.S441F	TCGA-44-A47A	LUAD	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.D825H	TCGA-4Z-AA80	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation rewiring degron network	0.1944
p.A838V	TCGA-4Z-AA83	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation rewiring degron network	0.2222
p.A676T	TCGA-AP-A0LM	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1944
p.R660M	TCGA-B5-A3FA	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1389
p.Q459E	TCGA-CN-6994	HNSC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.3056
p.F658L	TCGA-CQ-A4CD	HNSC	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0833
p.A830T	TCGA-DK-AA6Q	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation altering degron motif	0.7139
p.R456H	TCGA-E6-A1LX	UCEC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7133
p.N678S	TCGA-E7-A8O8	BLCA	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1389
p.S607L	TCGA-EJ-A7NN	PRAD	TCGA	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7667
p.N755H	TCGA-EO-A22R	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0833
p.V747A	TCGA-FI-A2D5	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.3056
p.Q661H	TCGA-L7-A56G	ESCA	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1667
p.N678D	TCGA-UB-A7MB	LIHC	TCGA	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1389
p.E466Q	TCGA-VS-A9V3	CESC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.S453C	DO44362	CESC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7541
p.G453R	DO8224	COAD	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7568
p.R606H	DO10892	GBM	ICGC	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.8244
p.N615I	DO231934	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1111
p.S455R	DO228952	LICA	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7427
p.P449Q	DO228971	LICA	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation blocking ubiquitination signal	0.75
p.S614R	DO229041	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.K451N	DO24297	LUAD	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6918
p.A447S	DO27088	LUSC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.N457S	DO219486	SKCM	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7069
p.K659N	DO50076	UCEC	ICGC	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1111
p.E440D	DO41235	UCEC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0556
p.V613A	DO41331	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.S841N	SIDM00216	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation rewiring degron network	0.1389
p.S841N	ACH-000989	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation rewiring degron network	0.1389
p.S841N	SNU-175	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	830:834	Mutation rewiring degron network	0.1389
p.S467R	SIDM00082	Melanoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation blocking phosphorylation signal	0.5278
p.S467R	SIDM00842	Colorectal Carcinoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation blocking phosphorylation signal	0.5278
p.N735S	SIDM00807	Bladder Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.N735S	5637	urinary tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.T461K	SIDM00677	Colorectal Carcinoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.T461K	ACH-000007	Colon/Colorectal Cancer	CCLE	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.T461K	LS-513	large intestine	COSMIC	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.S748N	SIDM01617	Endometrial Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2778
p.S748N	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.2778
p.R456C	ACH-001119	Lymphoma	CCLE	AREELSRLQ	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.719
p.N601S	5637	urinary tract	COSMIC	VDSSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.P663S	Daudi	haematopoietic and lymphoid tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	667:671	Mutation blocking phosphorylation signal	0.6667
p.F666L	Daudi	haematopoietic and lymphoid tissue	COSMIC	ATSST	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.3056
p.E749Q	U-698-M	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.25

Kaplan plot for EPS15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPS15

UniProt ID: P42566

Entrez ID: 2060

Protein name: Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPS15 in