DegronMD

Uniprot ID: P42566

Source protein: Epidermal growth factor receptor substrate 15

Source gene: EPS15

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9171

ASA_SCORE: 103.7

COIL: 0.0298

CONS_SCORE: 0.4267

DSS_SCORE: 0.4999

HELIX: 0.9713

FCONS_SCORE: 1.091

RIG_SCORE: 0.7377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S441F	TCGA-44-A47A	LUAD	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	0.0833
p.Q459E	TCGA-CN-6994	HNSC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	0.3056
p.R456H	TCGA-E6-A1LX	UCEC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	0.7133
p.E466Q	TCGA-VS-A9V3	CESC	TCGA	AREELSRLQ	DEG_APCC_DBOX_1	0.1111
p.S453C	DO44362	CESC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.7541
p.G453R	DO8224	COAD	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.7568
p.S455R	DO228952	LICA	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.7427
p.P449Q	DO228971	LICA	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.75
p.K451N	DO24297	LUAD	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.6918
p.A447S	DO27088	LUSC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.25
p.N457S	DO219486	SKCM	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.7069
p.E440D	DO41235	UCEC	ICGC	AREELSRLQ	DEG_APCC_DBOX_1	0.0556
p.S467R	SIDM00082	Melanoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	0.5278
p.S467R	SIDM00842	Colorectal Carcinoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	0.5278
p.T461K	SIDM00677	Colorectal Carcinoma	GDSC	AREELSRLQ	DEG_APCC_DBOX_1	0.25
p.T461K	ACH-000007	Colon/Colorectal Cancer	CCLE	AREELSRLQ	DEG_APCC_DBOX_1	0.25
p.T461K	LS-513	large_intestine	COSMIC	AREELSRLQ	DEG_APCC_DBOX_1	0.25
p.R456C	ACH-001119	Lymphoma	CCLE	AREELSRLQ	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P42566	Epidermal growth factor receptor substrate 15	DEG_APCC_DBOX_1	450:458	AREELSRLQ	APC,CDC20,FZR1	0.9171	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons