DegronMD - Q14980(NUMA1)

FUNCTION: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1810C	TCGA-A5-A0VP	UCEC	TCGA	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.R1810C	ACH-001841	Bile Duct Cancer	CCLE	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.R180H	TCGA-AJ-A3EL	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.R180H	DO41542	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.R180H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.R180H	ACH-000922	Leukemia	CCLE	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.R180H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1389
p.V1796I	TCGA-AX-A2HD	UCEC	TCGA	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.25
p.S1852Y	TCGA-B5-A1MX	UCEC	TCGA	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.8231
p.R1810H	TCGA-DU-7008	LGG	TCGA	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.R1810H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.R1810H	ACH-002256	Leukemia	CCLE	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.R1810H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1667
p.S198L	TCGA-TN-A7HJ	HNSC	TCGA	VASSS	DEG_SPOP_SBC_1	187:191	Mutation blocking phosphorylation signal	0.5833
p.S198L	DO219077	HNSC	ICGC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation blocking phosphorylation signal	0.5833
p.S200Y	DO228732	GACA	ICGC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation blocking phosphorylation signal	0.5278
p.G199S	DO232224	PBCA	ICGC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1111
p.I179V	DO229211	THCA	ICGC	VASSS	DEG_SPOP_SBC_1	187:191	Mutation rewiring degron network	0.1111
p.T1851A	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.6028
p.T1851A	ACH-000840	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.6028
p.T1851A	HCC-366	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.6028
p.R1802C	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM01005	Acute Myeloid Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM00589	Oral Cavity Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM00316	Glioblastoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM01448	Head and Neck Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM01658	Unknown	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.R1802C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.719
p.S1852T	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.7116
p.S1852T	ACH-000840	Lung Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.7116
p.S1852T	HCC-366	lung	COSMIC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation altering degron motif	0.7116
p.G1801S	SIDM00984	Other Blood Cancers	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.6993
p.G1801S	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.6993
p.G1801S	SIDM01157	Other Solid Cancers	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation altering degron motif	0.6993
p.A1841T	SIDM00799	Glioblastoma	GDSC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0833
p.A1841T	ACH-000558	Brain Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0833
p.A1841T	A172	central nervous system	COSMIC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0833
p.L1790P	SIDM00333	Endometrial Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.0833
p.L1790P	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.0833
p.L1790P	MFE-319	endometrium	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.0833
p.A1843T	SIDM01617	Endometrial Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.1389
p.A1843T	ACH-000994	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.1389
p.D1864N	SIDM01588	Endometrial Carcinoma	GDSC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0556
p.D1864N	ACH-000993	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0556
p.Q1845H	ACH-000954	Endometrial/Uterine Cancer	CCLE	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.1944
p.R1863H	SNU-1040	large intestine	COSMIC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.0833
p.R1796H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.25
p.R1861H	SNU-1040	large intestine	COSMIC	ATSST	DEG_SPOP_SBC_1	1850:1854	Mutation rewiring degron network	0.1389
p.R1794H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	1799:1804	Mutation rewiring degron network	0.1944

Kaplan plot for NUMA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUMA1

UniProt ID: Q14980

Entrez ID: 4926

Protein name: Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUMA1 in