DegronMD

Uniprot ID: Q14980

Source protein: Nuclear mitotic apparatus protein 1

Source gene: NUMA1

Class: DEG_SCF_TRCP1_1

Location: 1799:1804

E3 ligase: BTRC

DEGRON score: 0.9834

ASA_SCORE: 95.25

COIL: 0.7465

CONS_SCORE: 0.6216

DSS_SCORE: 0.4165

HELIX: 0.2298

FCONS_SCORE: 0.9615

RIG_SCORE: 0.7107

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1810C	TCGA-A5-A0VP	UCEC	TCGA	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.R1810C	ACH-001841	Bile Duct Cancer	CCLE	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.V1796I	TCGA-AX-A2HD	UCEC	TCGA	DSGRKT	DEG_SCF_TRCP1_1	0.25
p.R1810H	TCGA-DU-7008	LGG	TCGA	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.R1810H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.R1810H	ACH-002256	Leukemia	CCLE	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.R1810H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	0.1667
p.R1802C	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM01005	Acute Myeloid Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM00589	Oral Cavity Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM00316	Glioblastoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM01448	Head and Neck Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM01658	Unknown	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.R1802C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.719
p.G1801S	SIDM00984	Other Blood Cancers	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.6993
p.G1801S	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.6993
p.G1801S	SIDM01157	Other Solid Cancers	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.6993
p.L1790P	SIDM00333	Endometrial Carcinoma	GDSC	DSGRKT	DEG_SCF_TRCP1_1	0.0833
p.L1790P	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSGRKT	DEG_SCF_TRCP1_1	0.0833
p.L1790P	MFE-319	endometrium	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	0.0833
p.R1796H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	0.25
p.R1794H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRKT	DEG_SCF_TRCP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRKT

Degron related mutations and impact score

Drug responses associated with NUMA1 mutations

All proteins holding degron of DSGRKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14980	Nuclear mitotic apparatus protein 1	DEG_SCF_TRCP1_1	1799:1804	DSGRKT	BTRC	0.9834	More...