DegronMD - P10243(MYBL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S744G	TCGA-34-5929	LUSC	TCGA	ATSST	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.6993
p.S744G	DO26659	LUSC	ICGC	ATSST	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.6993
p.T479A	TCGA-85-6798	LUSC	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.825
p.T479A	DO27295	LUSC	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.825
p.P523H	TCGA-A5-A0G2	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.0556
p.P523H	DO41235	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.0556
p.G538R	TCGA-A8-A06R	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.3056
p.G538R	DO5165	BRCA	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.3056
p.A475V	TCGA-AA-3949	COAD	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.3056
p.A475V	DO7798	COAD	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.3056
p.N536H	TCGA-AP-A0LS	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation altering degron motif	0.7423
p.N536H	DO43178	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation altering degron motif	0.7423
p.K534N	TCGA-B5-A1MR	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation altering degron motif	0.6918
p.K534N	DO41758	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation altering degron motif	0.6918
p.G538E	TCGA-D3-A2JF	SKCM	TCGA	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.3056
p.G538E	DO38153	SKCM	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.3056
p.G466C	TCGA-DD-AADP	LIHC	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.G466C	DO52243	LIHC	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.0556
p.F486L	TCGA-MN-A4N4	LUAD	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.25
p.F486L	DO26250	LUAD	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.25
p.T479I	TCGA-V5-AASW	ESCA	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.8189
p.T479I	SIDM00511	Small Cell Lung Carcinoma	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.8189
p.T479I	ACH-000257	Lung Cancer	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.8189
p.T479I	COR-L279	lung	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.8189
p.D470N	DO233952	GACA	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1667
p.P488S	DO11854	GBM	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1944
p.T541K	DO229036	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation blocking phosphorylation signal	0.6667
p.L476I	DO232224	PBCA	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.6063
p.T483A	SIDM01023	Acute Myeloid Leukemia	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7139
p.T483A	ACH-000006	Leukemia	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7139
p.T483A	ACH-001129	Leukemia	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7139
p.T483A	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation altering degron motif	0.7139
p.Q490R	SIDM00487	Colorectal Carcinoma	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.Q490R	CCK-81	large intestine	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	476:483	Mutation rewiring degron network	0.1389
p.L524V	ACH-002834	Bone Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	533:537	Mutation rewiring degron network	0.0833

Kaplan plot for MYBL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBL1

UniProt ID: P10243

Entrez ID: 4603

Protein name: Myb-related protein A (A-Myb) (Myb-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBL1 in