DegronMD

Uniprot ID: P10243

Source protein: Myb-related protein A

Source gene: MYBL1

Class: DEG_SCF_FBW7_1

Location: 476:483

E3 ligase: FBXW7

DEGRON score: 0.5569

ASA_SCORE: 96.75

COIL: 0.8678

CONS_SCORE: 0.388

DSS_SCORE: 0.5019

HELIX: 0.0445

FCONS_SCORE: 0.9612

RIG_SCORE: 0.7403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T479A	TCGA-85-6798	LUSC	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	0.825
p.T479A	DO27295	LUSC	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.825
p.A475V	TCGA-AA-3949	COAD	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	0.3056
p.A475V	DO7798	COAD	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.3056
p.G466C	TCGA-DD-AADP	LIHC	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	0.0556
p.G466C	DO52243	LIHC	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.0556
p.F486L	TCGA-MN-A4N4	LUAD	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	0.25
p.F486L	DO26250	LUAD	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.25
p.T479I	TCGA-V5-AASW	ESCA	TCGA	LKHTPLKT	DEG_SCF_FBW7_1	0.8189
p.T479I	SIDM00511	Small Cell Lung Carcinoma	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	0.8189
p.T479I	ACH-000257	Lung Cancer	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	0.8189
p.T479I	COR-L279	lung	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	0.8189
p.D470N	DO233952	GACA	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.1667
p.P488S	DO11854	GBM	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.1944
p.L476I	DO232224	PBCA	ICGC	LKHTPLKT	DEG_SCF_FBW7_1	0.6063
p.T483A	SIDM01023	Acute Myeloid Leukemia	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	0.7139
p.T483A	ACH-000006	Leukemia	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	0.7139
p.T483A	ACH-001129	Leukemia	CCLE	LKHTPLKT	DEG_SCF_FBW7_1	0.7139
p.T483A	MONO-MAC-6	haematopoietic_and_lymphoid_tissue	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	0.7139
p.Q490R	SIDM00487	Colorectal Carcinoma	GDSC	LKHTPLKT	DEG_SCF_FBW7_1	0.1389
p.Q490R	CCK-81	large_intestine	COSMIC	LKHTPLKT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_SCF_FBW7_1	476:483	LKHTPLKT	FBXW7	0.5569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons