DegronMD

Uniprot ID: P10243

Source protein: Myb-related protein A

Source gene: MYBL1

Class: DEG_APCC_KENBOX_2

Location: 533:537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9267

ASA_SCORE: 106.52

COIL: 0.7904

CONS_SCORE: 0.3029

DSS_SCORE: 0.6501

HELIX: 0.1584

FCONS_SCORE: 0.8404

RIG_SCORE: 0.7215

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N536H	TCGA-AP-A0LS	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.7423
p.N536H	DO43178	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.7423
p.K534N	TCGA-B5-A1MR	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.6918
p.K534N	DO41758	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.6918
p.T541K	DO229036	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.6667
p.G538R	TCGA-A8-A06R	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	0.3056
p.G538R	DO5165	BRCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.3056
p.G538E	TCGA-D3-A2JF	SKCM	TCGA	QKENV	DEG_APCC_KENBOX_2	0.3056
p.G538E	DO38153	SKCM	ICGC	QKENV	DEG_APCC_KENBOX_2	0.3056
p.L524V	ACH-002834	Bone Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.0833
p.P523H	TCGA-A5-A0G2	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.0556
p.P523H	DO41235	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHB6	LIM domain and actin-binding protein 1	DEG_APCC_KENBOX_2	305:309	QKENV	APC,CDC20,FZR1	0.9766	More...
P10243	Myb-related protein A	DEG_APCC_KENBOX_2	533:537	QKENV	APC,CDC20,FZR1	0.9267	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	253:257	QKENV	APC,CDC20,FZR1	0.8632	More...
Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	DEG_APCC_KENBOX_2	40:44	QKENV	APC,CDC20,FZR1	0.9939	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons