DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_APCC_KENBOX_2

Location: 253:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8632

ASA_SCORE: 110.96

COIL: 0.6778

CONS_SCORE: 0.2735

DSS_SCORE: 0.3097

HELIX: 0.283

FCONS_SCORE: 0.6102

RIG_SCORE: 0.8064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L258Q	TCGA-55-7281	LUAD	TCGA	QKENV	DEG_APCC_KENBOX_2	0.3056
p.L258Q	DO25985	LUAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.3056
p.Q253P	TCGA-CR-7367	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.5924
p.Q253P	DO15999	HNSC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.5924
p.K245T	TCGA-D1-A103	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.5556
p.K245T	DO42312	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.5556
p.K254R	TCGA-DM-A28E	COAD	TCGA	QKENV	DEG_APCC_KENBOX_2	0.7237
p.K254R	DO7906	COAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.7237
p.K254N	TCGA-OL-A97C	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	0.6918
p.K254N	DO219640	BRCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.6918
p.G257A	DO49802	BLCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.754
p.V257D	DO227996	COCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.6674
p.K255R	DO222769	COCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.7237
p.E252K	DO20776	KIRP	ICGC	QKENV	DEG_APCC_KENBOX_2	0.3056
p.S247R	DO231986	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.1667
p.T251K	DO228976	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.7222
p.K245N	DO231344	THCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.5556
p.L264P	DO42256	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.5833
p.S246N	DO42560	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.25
p.L248M	ACH-001677	Lymphoma	CCLE	QKENV	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_APCC_KENBOX_2	533:537	QKENV	APC,CDC20,FZR1	0.9267	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	253:257	QKENV	APC,CDC20,FZR1	0.8632	More...
Q9UHB6	LIM domain and actin-binding protein 1	DEG_APCC_KENBOX_2	305:309	QKENV	APC,CDC20,FZR1	0.9766	More...
Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	DEG_APCC_KENBOX_2	40:44	QKENV	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons