DegronMD - P46013(MKI67)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1271K	TCGA-05-4424	LUAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1667
p.Y1737D	TCGA-17-Z004	LUAD	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation blocking phosphorylation signal	0.5833
p.L2197V	TCGA-18-3406	LUSC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.25
p.S507F	TCGA-22-5473	LUSC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking phosphorylation signal	0.6111
p.S507F	TCGA-YD-A89C	SKCM	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking phosphorylation signal	0.6111
p.P1112S	TCGA-2W-A8YY	CESC	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation altering degron motif	0.6752
p.E1465Q	TCGA-39-5029	LUSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.1111
p.D1499H	TCGA-3N-A9WB	SKCM	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.3056
p.L258Q	TCGA-55-7281	LUAD	TCGA	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.L258Q	DO25985	LUAD	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.S1131C	TCGA-55-A4DF	LUAD	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation blocking phosphorylation signal	0.6111
p.I51F	TCGA-56-8626	LUSC	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1667
p.I51F	DO45506	LUSC	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1667
p.K2097R	TCGA-66-2786	LUSC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation substituting flanking lysine	0.2222
p.A2102V	TCGA-68-7755	LUSC	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.0833
p.E1351K	TCGA-73-A9RS	LUAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.3056
p.A2102S	TCGA-77-A5GH	LUSC	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.0833
p.P2066A	TCGA-78-8640	LUAD	TCGA	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation altering degron motif	0.7503
p.D1466N	TCGA-85-8350	LUSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.1389
p.E1969K	TCGA-91-6829	LUAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.2778
p.E2090D	TCGA-A5-A0G1	UCEC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.E2435D	TCGA-A5-A0G2	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1111
p.H1020Y	TCGA-A5-A0G2	UCEC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6118
p.P1014Q	TCGA-A5-A0G2	UCEC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7035
p.P526S	TCGA-A5-A0VP	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.1389
p.R1081H	TCGA-A5-A1OF	UCEC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.1111
p.S771N	TCGA-A5-A2K5	UCEC	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1667
p.S771N	SIDM00493	Other Solid Cancers	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1667
p.S771N	NCI-H292	lung	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1667
p.T2212A	TCGA-A6-2686	COAD	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1944
p.D2169N	TCGA-A7-A6VX	BRCA	TCGA	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.1389
p.R1268Q	TCGA-AA-3984	COAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.25
p.R1268Q	SIDM00313	Hodgkin's Lymphoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.25
p.R1268Q	ACH-000702	Lymphoma	CCLE	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.25
p.R1268Q	L-1236	haematopoietic and lymphoid tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.25
p.T2455N	TCGA-AA-A010	COAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.6389
p.A1243T	TCGA-AA-A01R	COAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1667
p.P1356L	TCGA-AB-2828	LAML	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation altering degron motif	0.7582
p.I2340L	TCGA-AG-A002	READ	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.0833
p.I37T	TCGA-AJ-A23O	UCEC	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.5966
p.I37T	DO43290	UCEC	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.5966
p.L1221I	TCGA-AJ-A3EK	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.0833
p.R596H	TCGA-AJ-A3OJ	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.R596H	TCGA-AJ-A3OJ	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.P2360L	TCGA-AP-A051	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.R505H	TCGA-AP-A051	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.1111
p.R505H	SIDM00837	Colorectal Carcinoma	GDSC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.1111
p.R505H	SW48	large intestine	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.1111
p.E930D	TCGA-AP-A056	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.2778
p.E930D	TCGA-AP-A056	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.1111
p.R1738I	TCGA-AP-A059	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1667
p.E1361D	TCGA-AP-A0LM	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.2778
p.V841I	TCGA-AP-A0LM	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.5965
p.A1225T	TCGA-AP-A1DK	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1944
p.T2089I	TCGA-AP-A1DR	UCEC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.8189
p.R2120W	TCGA-AP-A1DV	UCEC	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.25
p.R2120W	SIDM02039	Colorectal Carcinoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.25
p.S853F	TCGA-AP-A1DV	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.6389
p.R503I	TCGA-AP-A1DV	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0556
p.R503I	TCGA-EO-A3B0	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0556
p.L2197F	TCGA-AP-A1E0	UCEC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.25
p.L2197F	ACH-002800	Unknown	CCLE	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.25
p.L576S	TCGA-AP-A1E0	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.0833
p.A1295V	TCGA-AP-A1E1	UCEC	TCGA	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.3056
p.K857Q	TCGA-AX-A05Z	UCEC	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking ubiquitination signal	0.5278
p.S1256P	TCGA-AX-A063	UCEC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking phosphorylation signal	0.7222
p.N935T	TCGA-AX-A06F	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation altering degron motif	0.7055
p.L1759I	TCGA-AX-A2HC	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1111
p.K944N	TCGA-AX-A2HC	UCEC	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation substituting flanking lysine	0.2222
p.P523A	TCGA-B0-4706	KIRC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.2222
p.S1750R	TCGA-B5-A11E	UCEC	TCGA	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7427
p.F1474S	TCGA-B5-A1MR	UCEC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation altering degron motif	0.6871
p.E924K	TCGA-BB-A5HY	HNSC	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.1111
p.P1140L	TCGA-BF-A3DL	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.7582
p.S1136T	TCGA-BG-A222	UCEC	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation blocking phosphorylation signal	0.75
p.R836T	TCGA-BH-A0BP	BRCA	TCGA	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1944
p.C1129R	TCGA-BK-A13B	UCEC	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1111
p.T1120S	TCGA-BR-4361	STAD	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.1944
p.I1976S	TCGA-BR-8680	STAD	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0833
p.D36E	TCGA-BR-A4CS	STAD	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.3056
p.D36E	DO47965	STAD	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.3056
p.N2054D	TCGA-BS-A0UF	UCEC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.0833
p.R596C	TCGA-BS-A0UF	UCEC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.R596C	TCGA-BS-A0UF	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.M2111V	TCGA-CG-5728	STAD	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.6097
p.P1250L	TCGA-CM-5861	COAD	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1111
p.Q253P	TCGA-CR-7367	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.5924
p.Q253P	DO15999	HNSC	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.5924
p.P2108S	TCGA-D1-A103	UCEC	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.25
p.K245T	TCGA-D1-A103	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation blocking ubiquitination signal	0.5556
p.K245T	DO42312	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation blocking ubiquitination signal	0.5556
p.P1250S	TCGA-D1-A16X	UCEC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1111
p.P1114S	TCGA-D3-A2J7	SKCM	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation altering degron motif	0.5641
p.R596S	TCGA-D3-A2JP	SKCM	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.R596S	TCGA-D3-A2JP	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.R529S	TCGA-D3-A2JP	SKCM	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0556
p.R1090T	TCGA-D6-A6EQ	HNSC	TCGA	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.6765
p.N2158T	TCGA-D8-A1XQ	BRCA	TCGA	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation altering degron motif	0.5944
p.G2058E	TCGA-D9-A1JW	SKCM	TCGA	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1944
p.G2058R	TCGA-D9-A1JW	SKCM	TCGA	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1944
p.H1486Q	TCGA-DD-AAEI	LIHC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.1667
p.R2359W	TCGA-DF-A2KU	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.25
p.I775N	TCGA-DI-A1BU	UCEC	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.0556
p.K1491E	TCGA-DK-A6AW	BLCA	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation substituting flanking lysine	0.1944
p.D751H	TCGA-DK-AA74	BLCA	TCGA	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.K254R	TCGA-DM-A28E	COAD	TCGA	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.7237
p.K254R	DO7906	COAD	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.7237
p.T2211R	TCGA-DX-AB2Z	SARC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation blocking phosphorylation signal	0.6667
p.D1953E	TCGA-E6-A1LX	UCEC	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1389
p.G1104A	TCGA-E8-A417	THCA	TCGA	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.2222
p.G1104A	TCGA-E8-A417	THCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.0833
p.P1132S	TCGA-EB-A5UL	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.P2106S	TCGA-EE-A3JD	SKCM	TCGA	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.1944
p.K2357N	TCGA-EO-A22R	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.3056
p.A2195D	TCGA-EO-A22R	UCEC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1944
p.K2343T	TCGA-EO-A3AV	UCEC	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation blocking ubiquitination signal	0.6111
p.K2343T	DO41211	UCEC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation blocking ubiquitination signal	0.6111
p.T1485P	TCGA-EO-A3AV	UCEC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation blocking phosphorylation signal	0.6389
p.P1133L	TCGA-ER-A19N	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.2222
p.Q2084H	TCGA-ER-A2NG	SKCM	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.647
p.R513I	TCGA-EY-A1GI	UCEC	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation altering degron motif	0.8102
p.S606N	TCGA-EY-A2OP	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7069
p.C1981Y	TCGA-F1-6874	STAD	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1389
p.T931I	TCGA-F1-6874	STAD	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.3056
p.T931I	TCGA-F1-6874	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.1389
p.T1484M	TCGA-F7-A624	HNSC	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.E1094Q	TCGA-FD-A6TC	BLCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.5633
p.P1463L	TCGA-FW-A3R5	SKCM	TCGA	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.0556
p.P1132L	TCGA-FW-A3R5	SKCM	TCGA	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.E2069Q	TCGA-G2-A2EO	BLCA	TCGA	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation altering degron motif	0.6744
p.E1715K	TCGA-GD-A2C5	BLCA	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.E1715K	TCGA-RR-A6KA	GBM	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.E1715K	SIDM01611	Endometrial Carcinoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.E1715K	ACH-000996	Endometrial/Uterine Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.3056
p.D518H	TCGA-GM-A2D9	BRCA	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation altering degron motif	0.6577
p.A2164T	TCGA-GN-A8LN	SKCM	TCGA	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.2778
p.Q1232H	TCGA-GU-AATO	BLCA	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation altering degron motif	0.647
p.K2000N	TCGA-GV-A3JX	BLCA	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation substituting flanking lysine	0.3056
p.E612K	TCGA-HE-7130	KIRP	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.D2436G	TCGA-HT-7882	LGG	TCGA	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1389
p.E2090K	TCGA-IR-A3LI	CESC	TCGA	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A591G	TCGA-IS-A3K7	SARC	TCGA	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation altering degron motif	0.6429
p.M948I	TCGA-JW-A5VJ	CESC	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.1667
p.E1730K	TCGA-JX-A3PZ	CESC	TCGA	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.E1730K	DO44400	CESC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.D942Y	TCGA-KK-A8I6	PRAD	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6214
p.R2161K	TCGA-L5-A8NK	ESCA	TCGA	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation altering degron motif	0.6126
p.K254N	TCGA-OL-A97C	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.6918
p.K254N	DO219640	BRCA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.6918
p.D2208Y	TCGA-OR-A5JA	ACC	TCGA	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.3056
p.R1513K	TCGA-P5-A5F1	LGG	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1667
p.R38H	TCGA-TM-A7C3	LGG	TCGA	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.8244
p.R38H	DO50222	LGG	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.8244
p.P1986A	TCGA-TM-A84H	LGG	TCGA	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.2778
p.P1014S	TCGA-VQ-A91D	STAD	TCGA	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6752
p.P1012Q	TCGA-X6-A8C3	SARC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.2778
p.G617A	TCGA-XF-A8HG	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0556
p.I1492M	TCGA-XF-A9SZ	BLCA	TCGA	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1111
p.E940Q	TCGA-XF-A9T5	BLCA	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.6744
p.D518N	TCGA-XF-A9T8	BLCA	TCGA	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation altering degron motif	0.5821
p.R2362K	TCGA-XF-AAMG	BLCA	TCGA	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.1667
p.E930K	TCGA-XF-AAN0	BLCA	TCGA	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.2778
p.E930K	TCGA-XF-AAN0	BLCA	TCGA	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation rewiring degron network	0.1111
p.S1264I	TCGA-ZJ-AAX8	CESC	TCGA	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.7341
p.E580Q	DO51925	BLCA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1944
p.I1132M	DO51919	BLCA	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1944
p.F2165C	DO48566	BLCA	ICGC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation substituting flanking lysine	0.3611
p.K1131E	DO48566	BLCA	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation blocking phosphorylation signal	0.6111
p.G257A	DO49802	BLCA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.754
p.D1309H	DO44029	BLCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.1389
p.P854T	DO44083	BLCA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1667
p.E2213K	DO219049	BLCA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1667
p.R2002K	DO219049	BLCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation blocking phosphorylation signal	0.5833
p.E1345K	DO496	BLCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.1389
p.E1355K	DO496	BLCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation altering degron motif	0.7022
p.E1355K	DO51167	GBM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation altering degron motif	0.7022
p.E1709Q	DO456	BLCA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.T938M	DO878	BOCA	ICGC	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.7423
p.T938M	LS-411N	large intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.7423
p.M1367I	DO220827	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation blocking ubiquitination signal	0.5556
p.R1760W	DO225396	BRCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.0833
p.R1760W	DO43186	UCEC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.0833
p.S2433N	DO228483	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.S2433N	DO229010	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.S2433N	DO229013	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.S2433N	DO229016	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.S2433N	DO229480	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.S2433N	DO231075	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.0556
p.R1516Q	DO228483	BRCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO229010	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO229013	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO229016	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO229480	LAML	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO228941	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO230536	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO231064	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.R1516Q	DO231075	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.0833
p.N2003S	DO228483	BRCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO229010	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO229013	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO229016	COCA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO228941	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO229053	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.N2003S	DO52365	LUSC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1111
p.T2360P	DO228483	BRCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T2360P	DO229010	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T2360P	DO229013	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T2360P	DO229016	COCA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T2360P	DO229480	LAML	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T2360P	DO228941	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.T1977N	DO228483	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.T1977N	DO229013	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.T1977N	DO229016	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.E1226D	DO1083	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.2222
p.E1243D	DO1285	BRCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1667
p.A1254T	DO5521	BRCA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.2222
p.S506L	DO51632	CESC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.1389
p.M588I	DO49974	CESC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation altering degron motif	0.7618
p.T1972M	DO49929	CESC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1944
p.T1972M	DO38551	STAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1944
p.P752S	DO223732	CESC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1667
p.A1466D	DO223732	CESC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.1389
p.T1302I	DO50090	COAD	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation altering degron motif	0.7078
p.K1100R	DO7828	COAD	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.1111
p.K1100R	DO7828	COAD	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.1944
p.E1014K	DO8730	COAD	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.E1014K	DO36556	READ	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.E1014K	DO43682	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.E1014K	DO41458	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.E1014K	DO41331	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.E1014K	DO43971	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.7022
p.R2194H	DO8479	COAD	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1667
p.R2194H	DO233878	GACA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1667
p.E2347K	DO9876	COAD	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2778
p.E2347K	DO52402	UCEC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2778
p.S510P	DO9876	COAD	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.25
p.T2114P	DO230326	COCA	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.7031
p.V257D	DO227996	COCA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.6674
p.A1952T	DO222755	COCA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1111
p.A1952T	DO21487	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1111
p.T1304R	DO222769	COCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.2778
p.K255R	DO222769	COCA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation altering degron motif	0.7237
p.T503A	DO222884	COCA	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0556
p.I1741T	DO229010	COCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO234285	ESAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO230659	LAML	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO231140	LAML	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO228947	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO229047	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.I1741T	DO230993	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.P1517L	DO229010	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking ubiquitination signal	0.5
p.P1517L	DO229016	COCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking ubiquitination signal	0.5
p.P1517L	DO228941	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking ubiquitination signal	0.5
p.P1517L	DO231075	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking ubiquitination signal	0.5
p.D1974H	DO234149	ESAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1389
p.D1974H	DO227499	LAML	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1389
p.S1756N	DO223038	ESCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation substituting flanking lysine	0.3056
p.D582N	DO222459	ESCA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.25
p.E2082K	DO218136	GACA	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.7022
p.E2101K	DO233146	GACA	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.0556
p.E2101K	DO42568	UCEC	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.0556
p.N1265K	DO233885	GACA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.6918
p.N1265K	DO229041	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.6918
p.T1023N	DO233937	GACA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.2778
p.A2441D	DO12184	GBM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking ubiquitination signal	0.7222
p.K1274N	DO14550	HNSC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.0833
p.D1248N	DO218995	HNSC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking ubiquitination signal	0.5
p.T1124M	DO44440	HNSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.0833
p.F2112L	DO219080	HNSC	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.6981
p.E2438G	DO14250	HNSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1944
p.E1954Q	DO15062	HNSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1667
p.E252K	DO20776	KIRP	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.3056
p.L851V	DO231223	LAML	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.25
p.A858T	DO22143	LGG	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.5
p.D2076G	DO22189	LGG	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.1667
p.D2076G	DO22189	LGG	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1389
p.R1153K	DO44556	LGG	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation blocking ubiquitination signal	0.5
p.S247R	DO231986	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1667
p.A1994T	DO228945	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation altering degron motif	0.7139
p.K1983R	DO228945	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation blocking phosphorylation signal	0.6389
p.A1224D	DO228948	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1667
p.A1224D	DO229009	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1667
p.S1312R	DO228948	LICA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.0556
p.S1312R	DO229019	LICA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.0556
p.D1227E	DO228950	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.25
p.P1012T	DO228974	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.2778
p.T251K	DO228976	LICA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation blocking ubiquitination signal	0.7222
p.P1149T	DO228985	LICA	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation rewiring degron network	0.1667
p.T1739N	DO228986	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1944
p.A1710D	DO229019	LICA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1667
p.D1263E	DO229019	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.6758
p.D1263E	DO229037	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.6758
p.T605K	DO229015	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7306
p.T2360K	DO229015	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2222
p.A1507E	DO229029	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7701
p.P600Q	DO229029	LICA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation substituting flanking lysine	0.2222
p.P600Q	DO229029	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	603:607	Mutation substituting flanking lysine	0.3611
p.T1488K	DO229028	LICA	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation substituting flanking lysine	0.2222
p.P1971T	DO229024	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.2222
p.T1494N	DO229027	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1667
p.T1025K	DO229026	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.2222
p.S1995R	DO229036	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation altering degron motif	0.7427
p.S1995R	DO229045	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation altering degron motif	0.7427
p.P2000T	DO229035	LICA	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation substituting flanking lysine	0.3056
p.H2363N	DO229035	LICA	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.1389
p.P1260T	DO229038	LICA	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.7031
p.P1706H	DO229037	LICA	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0556
p.P1510Q	DO229037	LICA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.25
p.H2211Q	DO229041	LICA	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation blocking phosphorylation signal	0.6667
p.E583K	DO229050	LICA	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2778
p.T1755K	DO229006	LICA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.2222
p.L1962I	DO229006	LICA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation altering degron motif	0.7174
p.T1027K	DO229006	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.1667
p.A1005D	DO229009	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.0833
p.L2057F	DO228901	LICA	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.L1469V	DO50922	LICA	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.G1352A	DO23220	LINC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation altering degron motif	0.754
p.P1138L	DO23108	LINC	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.7582
p.P1138L	DO45041	LINC	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.7582
p.D2198Y	DO218937	LUAD	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation blocking ubiquitination signal	0.7222
p.A1950S	DO218935	LUAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.R1476T	DO23759	LUAD	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation altering degron motif	0.7876
p.P1706A	DO45340	LUAD	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0556
p.S771C	DO45318	LUAD	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1667
p.G1958C	DO24656	LUAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation blocking ubiquitination signal	0.7222
p.K1740E	DO23610	LUAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation blocking phosphorylation signal	0.6667
p.T2356N	DO230525	LUSC	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation altering degron motif	0.8166
p.K1500I	DO230942	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7531
p.K1500I	DO224589	LUSC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7531
p.F749L	DO230961	LUSC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation blocking ubiquitination signal	0.5278
p.F749L	DO224594	LUSC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation blocking ubiquitination signal	0.5278
p.G846V	DO231114	LUSC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.7532
p.A1742V	DO26512	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.2778
p.K1737R	DO26419	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation blocking phosphorylation signal	0.5833
p.K2163N	DO50104	LUSC	ICGC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.3056
p.V529M	DO26423	LUSC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0556
p.D1106N	DO45492	LUSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation blocking ubiquitination signal	0.7222
p.P1482L	DO45482	LUSC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation blocking ubiquitination signal	0.7222
p.A1742S	DO45452	LUSC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.2778
p.E2072Q	DO45428	LUSC	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation blocking phosphorylation signal	0.5
p.E2072Q	DO45428	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation blocking phosphorylation signal	0.6944
p.Q525H	DO219161	LUSC	ICGC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking phosphorylation signal	0.6111
p.A1229T	DO219157	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.3056
p.H1094Q	DO219217	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.7582
p.E1105Q	DO27540	LUSC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.25
p.E1105Q	DO27540	LUSC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.0556
p.M1245I	DO27032	LUSC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation blocking ubiquitination signal	0.5556
p.M1245I	KM-H2	haematopoietic and lymphoid tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation blocking ubiquitination signal	0.5556
p.R2121K	DO228349	MALY	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.2222
p.R2121K	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.2222
p.G842E	DO220859	MELA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.7199
p.E2438K	DO222395	MELA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1944
p.S2103F	DO222644	MELA	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.1111
p.S2103F	DO47525	SKCM	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.1111
p.S2103F	DO219466	SKCM	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.1111
p.R849T	DO50684	ORCA	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.75
p.L1478V	DO46428	OV	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation altering degron motif	0.6765
p.D1508N	DO30280	OV	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking ubiquitination signal	0.75
p.E1961D	DO32247	OV	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation altering degron motif	0.6758
p.T1295I	DO28321	OV	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.3056
p.A2358T	DO46657	PAAD	ICGC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation rewiring degron network	0.2778
p.R1238Q	DO46657	PAAD	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.3056
p.R1238Q	DO43186	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.3056
p.A924E	DO35192	PACA	ICGC	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.1111
p.D2439Y	DO51474	PACA	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.2222
p.E1491D	DO232224	PBCA	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation substituting flanking lysine	0.1944
p.D582Y	DO219317	PRAD	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.25
p.D1263G	DO36389	READ	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.7198
p.K1096Q	DO36556	READ	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.3056
p.E1019D	DO37130	READ	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6758
p.G32D	DO46881	RECA	ICGC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1944
p.D1309N	DO229456	SKCA	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.1389
p.P1754S	DO218864	SKCA	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.H2211Y	DO37406	SKCM	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation blocking phosphorylation signal	0.6667
p.P772L	DO37406	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.P1103L	DO37406	SKCM	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.1944
p.P1103L	DO37406	SKCM	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.1111
p.P773L	DO37452	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1111
p.P1746S	DO50299	SKCM	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6752
p.H1240R	DO50293	SKCM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.25
p.T2460I	DO50281	SKCM	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.5
p.P754S	DO47695	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2222
p.P772S	DO47601	SKCM	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.Q1724H	DO47552	SKCM	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation blocking ubiquitination signal	0.75
p.P1018S	DO51267	SKCM	ICGC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6752
p.P1018S	MZ7-mel	skin	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6752
p.D1139H	DO51232	SKCM	ICGC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.7688
p.D839H	DO219503	SKCM	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.2778
p.T760S	DO38887	STAD	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation altering degron motif	0.7116
p.P1502L	DO38619	STAD	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7582
p.P1502L	451Lu	skin	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7582
p.M1751V	DO38619	STAD	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7208
p.K245N	DO231344	THCA	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation blocking ubiquitination signal	0.5556
p.E2069D	DO219773	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation altering degron motif	0.6758
p.C769R	DO40825	UCEC	ICGC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2222
p.S1312I	DO40884	UCEC	ICGC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.0556
p.K2113E	DO50076	UCEC	ICGC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.7022
p.K837E	DO43466	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.2222
p.T853S	DO42105	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.6389
p.K1264R	DO42312	UCEC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.7237
p.P1748S	DO42312	UCEC	ICGC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6752
p.S2207L	DO41050	UCEC	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.7667
p.K1079N	DO223282	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.0556
p.R1999W	DO223286	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.2222
p.L264P	DO42256	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation blocking phosphorylation signal	0.5833
p.A935V	DO43226	UCEC	ICGC	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation altering degron motif	0.6936
p.K1983T	DO52412	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation blocking phosphorylation signal	0.6389
p.K608T	DO52412	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	603:607	Mutation blocking ubiquitination signal	0.75
p.T1125P	DO52412	UCEC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.0556
p.G832E	DO52412	UCEC	ICGC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0833
p.N575T	DO41752	UCEC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation blocking phosphorylation signal	0.5
p.T1511A	DO52402	UCEC	ICGC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation blocking phosphorylation signal	0.6667
p.F1114S	DO41758	UCEC	ICGC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation altering degron motif	0.7982
p.L922F	DO41584	UCEC	ICGC	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.0556
p.K584N	DO41572	UCEC	ICGC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation blocking phosphorylation signal	0.75
p.E2204K	DO41903	UCEC	ICGC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.7022
p.T1275A	DO41903	UCEC	ICGC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking ubiquitination signal	0.5
p.T1489P	DO41903	UCEC	ICGC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.0833
p.T2148N	DO42568	UCEC	ICGC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation substituting flanking lysine	0.1944
p.E2075D	DO41235	UCEC	ICGC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.1389
p.E2075D	DO41235	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.S246N	DO42560	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation substituting flanking lysine	0.25
p.T1729I	DO43747	UCEC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1667
p.E1730D	DO42472	UCEC	ICGC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.1389
p.Q2435H	DO41133	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1111
p.T2456A	DO42745	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation rewiring degron network	0.1667
p.K1997N	DO42713	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.2778
p.Q2063H	DO41361	UCEC	ICGC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation altering degron motif	0.7582
p.P2000L	DO42673	UCEC	ICGC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation substituting flanking lysine	0.3056
p.T2460A	DO42633	UCEC	ICGC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.5
p.P1504L	SIDM01945	Colorectal Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation altering degron motif	0.7582
p.G2004R	SIDM00608	Plasma Cell Myeloma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM00607	Glioblastoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM00315	Glioblastoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM00040	Gastric Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM01439	Hepatocellular Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM01448	Head and Neck Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM01321	Pancreatic Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.G2004R	SIDM00164	Biliary Tract Carcinoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.0833
p.C1981F	SIDM00973	Melanoma	GDSC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1389
p.C1981F	ACH-000827	Skin Cancer	CCLE	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1389
p.C1981F	WM793B	skin	COSMIC	PVKTPTSS	DEG_SCF_FBW7_1	1988:1995	Mutation rewiring degron network	0.1389
p.P1707S	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.P1707S	ACH-000840	Lung Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.P1707S	HCC-366	lung	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.T1484A	SIDM01057	Acute Myeloid Leukemia	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.T1484A	SIDM01171	Glioblastoma	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.T1484A	SIDM01594	Breast Carcinoma	GDSC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.T1484A	GDM-1	haematopoietic and lymphoid tissue	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.T1484A	T98G	central nervous system	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation rewiring degron network	0.2222
p.Q2926K	SIDM01265	Plasma Cell Myeloma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00633	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM01099	Neuroblastoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00928	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00971	Breast Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00930	Osteosarcoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.Q2926K	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.5833
p.A756V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2778
p.A756V	ACH-000995	Leukemia	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2778
p.K1248I	SIDM00689	B-Lymphoblastic Leukemia	GDSC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking ubiquitination signal	0.5
p.K1248I	ACH-000151	Leukemia	CCLE	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking ubiquitination signal	0.5
p.K1248I	JM1	haematopoietic and lymphoid tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking ubiquitination signal	0.5
p.T2117I	SIDM00330	Neuroblastoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.7078
p.T2117I	ACH-001355	Neuroblastoma	CCLE	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.7078
p.T2117I	LAN-6	autonomic ganglia	COSMIC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation altering degron motif	0.7078
p.L1951I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0833
p.L1951I	SIDM00720	Mesothelioma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0833
p.L1951I	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0833
p.L1951I	SIDM01752	Pancreatic Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0833
p.L2073I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.0833
p.L2073I	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.2222
p.T1091M	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.8534
p.G1366A	SIDM01117	Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.1389
p.G1366A	ACH-002176	Lung Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.1389
p.G1366A	NCI-H748	lung	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.1389
p.P767L	SIDM00781	Colorectal Carcinoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2778
p.P767L	ACH-001199	Colon/Colorectal Cancer	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2778
p.P767L	SNU-C2B	large intestine	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.2778
p.F29L	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	IRIQLPVVS	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1111
p.T525M	SIDM00846	Cervical Carcinoma	GDSC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking phosphorylation signal	0.6111
p.T525M	HeLa	cervix	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking phosphorylation signal	0.6111
p.M1085K	SIDM00607	Glioblastoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.M1085K	SIDM00530	Esophageal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.M1085K	KYAE-1	oesophagus	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.S1750N	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7069
p.S1750N	ACH-000647	Esophageal Cancer	CCLE	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7069
p.S1750N	TE-1	oesophagus	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7069
p.M1085T	SIDM00231	Kidney Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.M1085T	ACH-002167	Kidney Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.M1085T	NCC010	kidney	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.N941T	SIDM00860	Head and Neck Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.7055
p.N941T	ACH-000846	Head and Neck Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.7055
p.N941T	FADU	upper aerodigestive tract	COSMIC	LKEND	DEG_APCC_KENBOX_2	938:942	Mutation altering degron motif	0.7055
p.Q2084R	SIDM00583	Pancreatic Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.6218
p.Q2084R	ACH-001107	Pancreatic Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.6218
p.Q2084R	KP-1N	pancreas	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.6218
p.T1298M	SIDM00660	Colorectal Carcinoma	GDSC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation altering degron motif	0.8534
p.T1298M	LS-411N	large intestine	COSMIC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation altering degron motif	0.8534
p.A1493D	SIDM00690	Head and Neck Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1389
p.A1493D	SIDM00836	Colorectal Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1389
p.A1493D	SIDM01318	Hepatocellular Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.1389
p.K1086N	SIDM00417	Plasma Cell Myeloma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation substituting flanking lysine	0.3611
p.K1086N	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation substituting flanking lysine	0.3611
p.K1086N	ACH-000626	Myeloma	CCLE	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation substituting flanking lysine	0.3611
p.K1086N	U-266	haematopoietic and lymphoid tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation substituting flanking lysine	0.3611
p.K1086N	MEG-01	haematopoietic and lymphoid tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation substituting flanking lysine	0.3611
p.T2093I	SIDM01134	Small Cell Lung Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.T2093I	SIDM01591	Breast Carcinoma	GDSC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.T2093I	ACH-000292	Lung Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.T2093I	ACH-000540	Non-Cancerous	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.T2093I	NCI-H841	lung	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.I1273M	SIDM00631	Breast Carcinoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1111
p.I1273M	ACH-001358	Breast Cancer	CCLE	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1111
p.I1273M	MDA-MB-330	breast	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1111
p.R832Q	SIDM00523	Small Cell Lung Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0833
p.R832Q	ACH-000698	Lung Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0833
p.R832Q	DMS-53	lung	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0833
p.S2453L	SIDM00995	Other Solid Cancers	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.6944
p.S2453L	ACH-001328	Skin Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.6944
p.S2453L	A431	skin	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking phosphorylation signal	0.6944
p.K2441E	SIDM00878	Breast Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking ubiquitination signal	0.7222
p.K2441E	ACH-000930	Breast Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking ubiquitination signal	0.7222
p.K2441E	HCC1569	breast	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation blocking ubiquitination signal	0.7222
p.D751Y	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.D751Y	ACH-000305	Esophageal Cancer	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.D751Y	EC-GI-10	oesophagus	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1389
p.T1977I	SIDM01045	Endometrial Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.T1977I	ACH-000978	Endometrial/Uterine Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.T1977I	EN	endometrium	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.0556
p.L1744P	SIDM01045	Endometrial Carcinoma	GDSC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6471
p.L1744P	ACH-000978	Endometrial/Uterine Cancer	CCLE	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6471
p.L1744P	EN	endometrium	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6471
p.D1252N	SIDM00487	Colorectal Carcinoma	GDSC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1667
p.D1252N	ACH-000963	Colon/Colorectal Cancer	CCLE	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1667
p.D1252N	CCK-81	large intestine	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation rewiring degron network	0.1667
p.I1015L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6063
p.I1015L	ACH-000917	Esophageal Cancer	CCLE	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6063
p.I1015L	TE-4	oesophagus	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6063
p.P2204S	SIDM00516	Melanoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.6752
p.P2204S	MZ7-mel	skin	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.6752
p.P2204A	SIDM00493	Other Solid Cancers	GDSC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.7503
p.P2204A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.7503
p.E1968D	SIDM00493	Other Solid Cancers	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.3056
p.E1968D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.3056
p.P1089S	SIDM00498	Colorectal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.6752
p.P1089S	SNU-C5	large intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation altering degron motif	0.6752
p.K1087R	SIDM00498	Colorectal Carcinoma	GDSC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2778
p.K1087R	ACH-000970	Colon/Colorectal Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2778
p.K1087R	SNU-C5	large intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2778
p.Q1497L	SIDM00898	Breast Carcinoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.25
p.Q1497L	ACH-000248	Breast Cancer	CCLE	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.25
p.Q1497L	AU565	breast	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.25
p.T1732S	SIDM00208	Glioblastoma	GDSC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.T1732S	ACH-002229	Brain Cancer	CCLE	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.T1732S	D-502MG	central nervous system	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0833
p.D2940N	SIDM00794	Other Solid Cancers	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.0833
p.D2940N	ACH-000975	Lung Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.0833
p.D2940N	ACH-001442	Skin Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.0833
p.D2940N	A388	skin	COSMIC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.0833
p.K850E	SIDM00989	Bladder Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking ubiquitination signal	0.7222
p.K850E	ACH-000802	Bladder Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking ubiquitination signal	0.7222
p.K850E	BFTC-905	urinary tract	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking ubiquitination signal	0.7222
p.R831T	SIDM00989	Bladder Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0556
p.R831T	ACH-000802	Bladder Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0556
p.R831T	BFTC-905	urinary tract	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0556
p.P1498S	SIDM00793	Burkitt's Lymphoma	GDSC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.2778
p.P1498S	ACH-002236	Lymphoma	CCLE	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.2778
p.T2927A	SIDM00217	Colorectal Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.825
p.T2927A	ACH-000999	Colon/Colorectal Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.825
p.T2927A	SNU-1040	large intestine	COSMIC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation altering degron motif	0.825
p.A2164V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.2778
p.A2164V	ACH-001127	Leukemia	CCLE	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.2778
p.A2164V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation rewiring degron network	0.2778
p.E750G	SIDM00256	Neuroblastoma	GDSC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1111
p.E750G	ACH-002281	Neuroblastoma	CCLE	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1111
p.E750G	NB14	autonomic ganglia	COSMIC	MFKTPVKE	DEG_SCF_FBW7_2	758:765	Mutation rewiring degron network	0.1111
p.G2448D	SIDM00554	Ovarian Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation altering degron motif	0.6087
p.G2448D	ACH-000524	Ovarian Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation altering degron motif	0.6087
p.G2448D	KURAMOCHI	ovary	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	2443:2450	Mutation altering degron motif	0.6087
p.D1973N	SIDM00118	Colorectal Carcinoma	GDSC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1667
p.D1973N	ACH-001081	Colon/Colorectal Cancer	CCLE	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1667
p.D1973N	HCC2998	large intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation rewiring degron network	0.1667
p.S853Y	SIDM00118	Colorectal Carcinoma	GDSC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.6389
p.S853Y	ACH-001081	Colon/Colorectal Cancer	CCLE	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.6389
p.S853Y	HCC2998	large intestine	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation blocking phosphorylation signal	0.6389
p.Q2202H	SIDM01567	Hodgkin's Lymphoma	GDSC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.647
p.Q2202H	ACH-000069	Lymphoma	CCLE	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.647
p.T2057S	SIDM00959	Acute Myeloid Leukemia	GDSC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.T2057S	ACH-000641	Leukemia	CCLE	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.T2057S	ACH-001036	Leukemia	CCLE	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.T2057S	CMK	haematopoietic and lymphoid tissue	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.1667
p.L2918P	SIDM01588	Endometrial Carcinoma	GDSC	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.1667
p.L2918P	ACH-000993	Endometrial/Uterine Cancer	CCLE	LSQTPGHT	DEG_SCF_FBW7_1	2924:2931	Mutation rewiring degron network	0.1667
p.P2107L	SIDM01761	Rhabdomyosarcoma	GDSC	MDTPTST	DEG_SCF_FBW7_1	2111:2117	Mutation rewiring degron network	0.2222
p.T1019S	SIDM01619	Endometrial Carcinoma	GDSC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6005
p.T1019S	ACH-000984	Endometrial/Uterine Cancer	CCLE	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation altering degron motif	0.6005
p.V1478I	ACH-000308	Ovarian Cancer	CCLE	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation altering degron motif	0.5965
p.I2205V	ACH-000386	Leukemia	CCLE	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.5965
p.I2205V	KG-1	haematopoietic and lymphoid tissue	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation altering degron motif	0.5965
p.G2078A	ACH-000690	Lung Cancer	CCLE	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.G2078A	ACH-000690	Lung Cancer	CCLE	PRTPKEE	DEG_SCF_FBW7_2	2063:2069	Mutation rewiring degron network	0.0833
p.G510V	ACH-000887	Brain Cancer	CCLE	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.25
p.E2199Q	ACH-001411	Bladder Cancer	CCLE	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.3056
p.E926G	ACH-001608	Brain Cancer	CCLE	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation rewiring degron network	0.1667
p.L248M	ACH-001677	Lymphoma	CCLE	QKENV	DEG_APCC_KENBOX_2	253:257	Mutation rewiring degron network	0.1944
p.P1477L	ACH-001843	Bile Duct Cancer	CCLE	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation altering degron motif	0.7582
p.A604V	ACH-001853	Bile Duct Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.5825
p.E2214Q	ACH-001864	Bile Duct Cancer	CCLE	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1389
p.Y932F	ACH-002061	Leukemia	CCLE	YKENI	DEG_APCC_KENBOX_2	932:936	Mutation altering degron motif	0.6417
p.T1757I	LAN-6	autonomic ganglia	COSMIC	LVDTPTSS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1667
p.E2167D	HCT-116	large intestine	COSMIC	INVFRE	LIG_APCC_ABBA_1	2157:2162	Mutation blocking ubiquitination signal	0.6389
p.G1958D	HT	haematopoietic and lymphoid tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation blocking ubiquitination signal	0.7222
p.T1295K	HuH-7	liver	COSMIC	MHTPKPS	DEG_SCF_FBW7_1	1296:1302	Mutation rewiring degron network	0.3056
p.S1344C	OVKATE	ovary	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation rewiring degron network	0.1111
p.K597N	NCI-H1915	lung	COSMIC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1944
p.K597N	NCI-H1915	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1667
p.K1256R	H290	pleura	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking phosphorylation signal	0.7222
p.N581T	FADU	upper aerodigestive tract	COSMIC	PRKTPVAS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.G2088D	KURAMOCHI	ovary	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation altering degron motif	0.7198
p.E520D	KYSE-270	oesophagus	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.3056
p.K2081E	HCC1569	breast	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.3056
p.A841T	NCI-H2342	lung	COSMIC	VAKTPRNT	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.7139
p.P528H	639-V	urinary tract	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation blocking ubiquitination signal	0.5278
p.Q1724R	KP-1N	pancreas	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation blocking ubiquitination signal	0.75
p.S2093L	A431	skin	COSMIC	LFQTPDHT	DEG_SCF_FBW7_1	2082:2089	Mutation rewiring degron network	0.2222
p.F1963L	NCI-H630	large intestine	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1960:1967	Mutation altering degron motif	0.6981
p.A1085T	HCT-15	large intestine	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.2222
p.G1006A	NCI-H748	lung	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.1111
p.Q1259P	CAL-12T	lung	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation altering degron motif	0.7035
p.L2199M	LoVo	large intestine	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.3056
p.T1509A	OACp4C	oesophagus	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.2778
p.T1509A	NCI-H187	lung	COSMIC	PVDTPTSS	DEG_SCF_FBW7_1	1500:1507	Mutation rewiring degron network	0.2778
p.P1347S	HCC-366	lung	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1352:1359	Mutation blocking phosphorylation signal	0.6389
p.T1733I	NCI-H841	lung	COSMIC	LFQTPSHT	DEG_SCF_FBW7_1	1716:1723	Mutation rewiring degron network	0.0556
p.A1222V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1111
p.A1101T	COLO-679	skin	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.1389
p.A1101T	COLO-679	skin	COSMIC	PRTPKEE	DEG_SCF_FBW7_2	1089:1095	Mutation rewiring degron network	0.1667
p.L1234F	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation altering degron motif	0.6981
p.R1272W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PVDTPTST	DEG_SCF_FBW7_1	1258:1265	Mutation blocking phosphorylation signal	0.5833
p.Q1137L	AU565	breast	COSMIC	VDTPTST	DEG_SCF_FBW7_1	1137:1143	Mutation altering degron motif	0.7765
p.Q1223R	PF-382	haematopoietic and lymphoid tissue	COSMIC	LFQTPGHT	DEG_SCF_FBW7_1	1230:1237	Mutation rewiring degron network	0.1389
p.K2192N	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	LFQTPICT	DEG_SCF_FBW7_1	2200:2207	Mutation rewiring degron network	0.1111
p.T1488M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LFQTPVCT	DEG_SCF_FBW7_1	1473:1480	Mutation substituting flanking lysine	0.2222
p.G2339S	SCaBER	urinary tract	COSMIC	PVDTPAST	DEG_SCF_FBW7_1	2349:2356	Mutation substituting flanking lysine	0.1667
p.T1124A	T98G	central nervous system	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.0833
p.T1124A	GDM-1	haematopoietic and lymphoid tissue	COSMIC	LFQTPGPS	DEG_SCF_FBW7_1	1108:1115	Mutation rewiring degron network	0.0833
p.E504D	NCI-H1155	lung	COSMIC	RPELFDE	LIG_APCC_ABBAyCdc20_2	513:519	Mutation rewiring degron network	0.0833
p.K1010T	HCC2998	large intestine	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	1014:1021	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MKI67

UniProt ID: P46013

Entrez ID: 4288

Protein name: Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MKI67 in