DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_SCF_FBW7_1

Location: 1014:1021

E3 ligase: FBXW7

DEGRON score: 0.8053

ASA_SCORE: 92.925

COIL: 0.9073

CONS_SCORE: 0.235

DSS_SCORE: 0.6388

HELIX: 0.0348

FCONS_SCORE: 0.9256

RIG_SCORE: 0.6816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1020Y	TCGA-A5-A0G2	UCEC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	0.6118
p.P1014Q	TCGA-A5-A0G2	UCEC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	0.7035
p.P1014S	TCGA-VQ-A91D	STAD	TCGA	PINTPTHT	DEG_SCF_FBW7_1	0.6752
p.P1012Q	TCGA-X6-A8C3	SARC	TCGA	PINTPTHT	DEG_SCF_FBW7_1	0.2778
p.E1014K	DO8730	COAD	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.E1014K	DO36556	READ	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.E1014K	DO43682	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.E1014K	DO41458	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.E1014K	DO41331	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.E1014K	DO43971	UCEC	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.7022
p.T1023N	DO233937	GACA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.2778
p.P1012T	DO228974	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.2778
p.T1025K	DO229026	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.2222
p.T1027K	DO229006	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.1667
p.A1005D	DO229009	LICA	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.0833
p.E1019D	DO37130	READ	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.6758
p.P1018S	DO51267	SKCM	ICGC	PINTPTHT	DEG_SCF_FBW7_1	0.6752
p.P1018S	MZ7-mel	skin	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	0.6752
p.I1015L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PINTPTHT	DEG_SCF_FBW7_1	0.6063
p.I1015L	ACH-000917	Esophageal Cancer	CCLE	PINTPTHT	DEG_SCF_FBW7_1	0.6063
p.I1015L	TE-4	oesophagus	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	0.6063
p.T1019S	SIDM01619	Endometrial Carcinoma	GDSC	PINTPTHT	DEG_SCF_FBW7_1	0.6005
p.T1019S	ACH-000984	Endometrial/Uterine Cancer	CCLE	PINTPTHT	DEG_SCF_FBW7_1	0.6005
p.G1006A	NCI-H748	lung	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	0.1111
p.K1010T	HCC2998	large_intestine	COSMIC	PINTPTHT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46013	Proliferation marker protein Ki-67	DEG_SCF_FBW7_1	1014:1021	PINTPTHT	FBXW7	0.8053	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons