DegronMD

Uniprot ID: P46013

Source protein: Proliferation marker protein Ki-67

Source gene: MKI67

Class: DEG_APCC_KENBOX_2

Location: 938:942

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9316

ASA_SCORE: 100.96

COIL: 0.6242

CONS_SCORE: 0.367

DSS_SCORE: 0.4509

HELIX: 0.3026

FCONS_SCORE: 1.1839

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E930D	TCGA-AP-A056	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1111
p.T931I	TCGA-F1-6874	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1389
p.M948I	TCGA-JW-A5VJ	CESC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1667
p.D942Y	TCGA-KK-A8I6	PRAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.6214
p.E940Q	TCGA-XF-A9T5	BLCA	TCGA	LKEND	DEG_APCC_KENBOX_2	0.6744
p.E930K	TCGA-XF-AAN0	BLCA	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1111
p.T938M	DO878	BOCA	ICGC	LKEND	DEG_APCC_KENBOX_2	0.7423
p.T938M	LS-411N	large_intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.7423
p.N941T	SIDM00860	Head and Neck Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	0.7055
p.N941T	ACH-000846	Head and Neck Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.7055
p.N941T	FADU	upper_aerodigestive_tract	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons