DegronMD

Uniprot ID: O15344

Source protein: E3 ubiquitin-protein ligase Midline-1

Source gene: MID1

Class: DEG_APCC_KENBOX_2

Location: 320:324

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7656

ASA_SCORE: 102.7

COIL: 0.7374

CONS_SCORE: 0.4046

DSS_SCORE: 0.3719

HELIX: 0.2528

FCONS_SCORE: 1.1162

RIG_SCORE: 0.7095

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S319T	TCGA-21-5782	LUSC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.S319T	DO27120	LUSC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.A332V	TCGA-A5-A0G2	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1111
p.A332V	DO41235	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1111
p.H325Y	TCGA-BR-6705	STAD	TCGA	LKEND	DEG_APCC_KENBOX_2	0.3056
p.H325Y	DO38835	STAD	ICGC	LKEND	DEG_APCC_KENBOX_2	0.3056
p.R327H	TCGA-EO-A3KU	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.25
p.R327H	DO50079	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.25
p.E322K	SW954	vulva	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons