DegronMD

Uniprot ID: P29374

Source protein: AT-rich interactive domain-containing protein 4A

Source gene: ARID4A

Class: DEG_APCC_KENBOX_2

Location: 744:748

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5299

ASA_SCORE: 108

COIL: 0.6874

CONS_SCORE: 0.3403

DSS_SCORE: 0.5557

HELIX: 0.2924

FCONS_SCORE: 0.8913

RIG_SCORE: 0.7333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K738N	TCGA-BK-A6W3	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.2778
p.K738N	DO50076	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.2778
p.E756D	TCGA-EO-A3B0	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	0.1111
p.E756D	DO219773	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	0.1111
p.P737S	SIDM00216	Colorectal Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	0.1389
p.P737S	ACH-000989	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.1389
p.P737S	SNU-175	large_intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.1389
p.Q751K	SIDM00887	Other Solid Cancers	GDSC	LKEND	DEG_APCC_KENBOX_2	0.25
p.Q751K	ACH-000211	Brain Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	0.25
p.Q751K	Daoy	central_nervous_system	COSMIC	LKEND	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15344	E3 ubiquitin-protein ligase Midline-1	DEG_APCC_KENBOX_2	320:324	LKEND	APC,CDC20,FZR1	0.7656	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_APCC_KENBOX_2	744:748	LKEND	APC,CDC20,FZR1	0.5299	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	938:942	LKEND	APC,CDC20,FZR1	0.9316	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	1071:1075	LKEND	APC,CDC20,FZR1	0.9955	More...
Q14739	Delta	DEG_APCC_KENBOX_2	49:53	LKEND	APC,CDC20,FZR1	0.9324	More...
Q8NI35	InaD-like protein	DEG_APCC_KENBOX_2	179:183	LKEND	APC,CDC20,FZR1	0.9898	More...
Q92743	Serine protease HTRA1	DEG_APCC_KENBOX_2	428:432	LKEND	APC,CDC20,FZR1	0.9566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons