DegronMD - Q12923(PTPN13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1754L	TCGA-06-5416	GBM	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1944
p.S1754L	TCGA-AA-3510	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1944
p.S1754L	TCGA-AJ-A5DW	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1944
p.S1754L	TCGA-EO-A3AY	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1944
p.E2072K	TCGA-17-Z026	LUAD	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.2222
p.E317K	TCGA-2J-AAB6	PAAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation altering degron motif	0.7022
p.E317K	DO51656	PAAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation altering degron motif	0.7022
p.T1469I	TCGA-2W-A8YY	CESC	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.3056
p.T1469I	DO223732	CESC	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.3056
p.D1736Y	TCGA-64-5781	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0833
p.C2234F	TCGA-78-7220	LUAD	TCGA	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation altering degron motif	0.7108
p.V1997L	TCGA-91-6848	LUAD	TCGA	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.3056
p.L1071V	TCGA-A5-A1OF	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation altering degron motif	0.5654
p.L1071V	DO42568	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation altering degron motif	0.5654
p.V1076G	TCGA-A5-A1OF	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.3056
p.V1076G	DO42568	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.3056
p.L2077I	TCGA-A5-A2K5	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7174
p.L2077I	TCGA-EO-A3B0	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7174
p.T406A	TCGA-AD-5900	COAD	TCGA	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.T406A	DO8514	COAD	ICGC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.T406A	DO227802	COCA	ICGC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1944
p.H325R	TCGA-AD-6889	COAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1111
p.H325R	DO8463	COAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1111
p.K1072Q	TCGA-AG-A002	READ	TCGA	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation altering degron motif	0.6944
p.R2247G	TCGA-AJ-A3EK	UCEC	TCGA	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.0833
p.I1601M	TCGA-AN-A046	BRCA	TCGA	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation altering degron motif	0.7618
p.I1601M	DO1285	BRCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation altering degron motif	0.7618
p.R1222C	TCGA-AP-A0LP	UCEC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.8301
p.R1222C	DO43146	UCEC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.8301
p.E2080K	TCGA-AX-A05Z	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7022
p.E2080K	TCGA-GN-A8LK	SKCM	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7022
p.E2080K	ACH-001569	Skin Cancer	CCLE	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7022
p.P1739H	TCGA-AZ-4315	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1667
p.P1735T	TCGA-B5-A3FA	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0556
p.P326H	TCGA-BF-A1PU	SKCM	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0833
p.P326H	DO50278	SKCM	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0833
p.D1756H	TCGA-BH-A2L8	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1389
p.L1225M	TCGA-BJ-A191	THCA	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.711
p.L1225M	DO40167	THCA	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.711
p.R323H	TCGA-BR-6852	STAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.R323H	TCGA-D8-A1X9	BRCA	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.R323H	DO5472	BRCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.R323H	DO233837	GACA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.R323H	DO38202	STAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.R323H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1667
p.A2084S	TCGA-BS-A0TC	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7588
p.S1747L	TCGA-C5-A1M8	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation altering degron motif	0.7667
p.K2245N	TCGA-CN-A63W	HNSC	TCGA	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.1389
p.G1998E	TCGA-CV-7250	HNSC	TCGA	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7199
p.R1969I	TCGA-D3-A2JO	SKCM	TCGA	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.8102
p.S1994F	TCGA-D3-A8GI	SKCM	TCGA	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2222
p.A1613T	TCGA-DA-A95X	SKCM	TCGA	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.A1613T	DO219480	SKCM	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.P1973S	TCGA-DA-A95Z	SKCM	TCGA	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.7222
p.S302F	TCGA-DF-A2KU	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.S302F	TCGA-W3-AA1O	SKCM	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.S302F	DO51274	SKCM	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.S302F	DO223286	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.H1759Y	TCGA-EB-A41A	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0556
p.G2237W	TCGA-EE-A29X	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation altering degron motif	0.7825
p.D310G	TCGA-EO-A22R	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2778
p.D310G	DO42713	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2778
p.S1085Y	TCGA-EO-A22R	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation blocking phosphorylation signal	0.5
p.S1085Y	DO42713	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation blocking phosphorylation signal	0.5
p.E1230D	TCGA-EO-A22X	UCEC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.3056
p.E1230D	DO43907	UCEC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.3056
p.R402L	TCGA-ER-A19P	SKCM	TCGA	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.R402L	DO47623	SKCM	ICGC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.G1993C	TCGA-ER-A19P	SKCM	TCGA	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1944
p.T308I	TCGA-EY-A1GU	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2222
p.T308I	DO41518	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2222
p.G2089C	TCGA-FS-A1Z0	SKCM	TCGA	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation substituting flanking lysine	0.3333
p.K1456N	TCGA-FS-A1ZM	SKCM	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.1944
p.K1456N	DO37731	SKCM	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.1944
p.P1467Q	TCGA-H4-A2HO	BLCA	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation altering degron motif	0.7035
p.P1467Q	DO494	BLCA	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation altering degron motif	0.7035
p.P1467Q	SIDM01950	Colorectal Carcinoma	GDSC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation altering degron motif	0.7035
p.Y407H	TCGA-IB-7651	PAAD	TCGA	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.Y407H	DO46657	PAAD	ICGC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.H325N	TCGA-KQ-A41N	BLCA	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1111
p.H325N	DO223588	BLCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1111
p.D1212H	TCGA-MA-AA42	CESC	TCGA	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.0833
p.D1212H	DO219724	CESC	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.0833
p.S1067F	TCGA-OD-A75X	SKCM	TCGA	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.2222
p.S1067F	DO48601	SKCM	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.2222
p.S1749C	TCGA-UY-A8OC	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation altering degron motif	0.7541
p.G1740R	TCGA-UY-A9PF	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1944
p.L305F	TCGA-VQ-A91V	STAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1389
p.L305F	DO222356	STAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1389
p.S1459C	TCGA-XF-A9SZ	BLCA	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.2778
p.S1459C	DO51919	BLCA	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.2778
p.G1238D	DO225070	BRCA	ICGC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.0833
p.E327Q	DO225334	BRCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.D2244N	DO1071	BRCA	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation substituting flanking lysine	0.2778
p.V1739I	DO51734	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1667
p.G2015C	DO10662	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0556
p.D1974N	DO8634	COAD	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation substituting flanking lysine	0.3611
p.P1997S	DO9876	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.3056
p.R2014W	DO8264	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.S1611Y	DO222884	COCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1944
p.G1745R	DO219916	DLBC	ICGC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation altering degron motif	0.7568
p.S2246F	DO234276	ESAD	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.1111
p.N1971S	DO234199	ESAD	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.7069
p.S1082N	DO233107	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation blocking phosphorylation signal	0.5833
p.E1755D	DO233213	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1667
p.V1993I	DO233791	GACA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1944
p.V1993I	huH-1	liver	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1944
p.F1981L	DO233950	GACA	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.0556
p.N1074H	DO233951	GACA	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation altering degron motif	0.7423
p.F2086L	DO220484	KICH	ICGC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.3056
p.E1755V	DO223668	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1667
p.A319S	DO228976	LICA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2778
p.C2229F	DO229029	LICA	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.1944
p.V2009F	DO229037	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.2222
p.A1988S	DO229045	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0556
p.V1989L	DO229009	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.G1596C	DO50880	LICA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.2222
p.V1069A	DO45265	LIRI	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.2778
p.G1457R	DO229177	LMS	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.2222
p.V1069I	DO229177	LMS	ICGC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.2778
p.D2247H	DO45462	LUSC	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.0833
p.N1616D	DO222843	MELA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation substituting flanking lysine	0.1667
p.G2082R	DO222908	MELA	ICGC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation altering degron motif	0.7568
p.L1597H	DO32337	OV	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.25
p.P1595L	DO218863	SKCA	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1944
p.G2225W	DO37715	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.0833
p.L1600I	DO37707	SKCM	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation altering degron motif	0.6063
p.G2015S	DO37406	SKCM	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0556
p.G2003S	DO37471	SKCM	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.6993
p.H1972N	DO47623	SKCM	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.75
p.G2235E	DO51763	STAD	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation altering degron motif	0.7199
p.S423Y	DO229240	THCA	ICGC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.A2004D	DO40670	THCA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7793
p.T2002M	DO42384	UCEC	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7423
p.T2002M	DO42568	UCEC	ICGC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7423
p.G1615D	DO42280	UCEC	ICGC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.0833
p.Y2088D	DO43154	UCEC	ICGC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.25
p.F2086S	DO43755	UCEC	ICGC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.3056
p.L2241I	DO41361	UCEC	ICGC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.25
p.A319T	SIDM02050	Colorectal Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.2778
p.H408R	SIDM01293	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.25
p.A1738T	SIDM00973	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1389
p.G1991D	SIDM00371	Pancreatic Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.G1991D	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.G1991D	IA-LM	lung	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.G1991D	SUIT-2	pancreas	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.I421V	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.I421V	SIDM00142	Endometrial Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.G1237E	SIDM00087	Plasma Cell Myeloma	GDSC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.1111
p.G1237E	ACH-000817	Myeloma	CCLE	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.1111
p.G1237E	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.1111
p.R2247K	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.0833
p.R2247K	A427	lung	COSMIC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.0833
p.R402Q	SIDM00193	Colorectal Carcinoma	GDSC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.R402Q	ACH-000991	Colon/Colorectal Cancer	CCLE	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.R402Q	SNU-81	large intestine	COSMIC	VFSTS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.R1222G	SIDM00090	Ovarian Carcinoma	GDSC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.7568
p.R1222G	ACH-000696	Ovarian Cancer	CCLE	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.7568
p.R1222G	OVCAR-8	ovary	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.7568
p.G1998R	SIDM00151	Ovarian Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7568
p.G1998R	ACH-000966	Ovarian Cancer	CCLE	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7568
p.G1998R	IGROV-1	ovary	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7568
p.P1593S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.P1593S	ACH-000917	Esophageal Cancer	CCLE	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.P1593S	TE-4	oesophagus	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.Y1758C	SIDM00181	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0833
p.Y1758C	SIDM01646	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0833
p.Y1758C	ACH-002358	Non-Cancerous	CCLE	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0833
p.P1976L	SIDM00898	Breast Carcinoma	GDSC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1944
p.P1976L	ACH-000248	Breast Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1944
p.P1976L	AU565	breast	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1944
p.A1613P	SIDM00884	Breast Carcinoma	GDSC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.A1613P	HCC1395	breast	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.1389
p.D1476Y	SIDM00534	Colorectal Carcinoma	GDSC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.1111
p.D1476Y	ACH-000986	Colon/Colorectal Cancer	CCLE	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.1111
p.D1476Y	HT-115	large intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.1111
p.R322H	SIDM00839	Colorectal Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1944
p.R322H	ACH-000950	Colon/Colorectal Cancer	CCLE	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1944
p.R322H	LoVo	large intestine	COSMIC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.1944
p.M2095I	SIDM00381	Cervical Carcinoma	GDSC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.0556
p.M2095I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.0556
p.E327K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.E327K	ACH-000912	Lung Cancer	CCLE	DFSSGE	DEG_Kelch_Keap1_1	312:317	Mutation rewiring degron network	0.0556
p.C2088R	SIDM00228	Thyroid Gland Carcinoma	GDSC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.25
p.C2088R	ACH-000897	Thyroid Cancer	CCLE	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.25
p.P1735L	SIDM01772	Mesothelioma	GDSC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.0556
p.T1603A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation altering degron motif	0.7139
p.T1603A	ACH-000942	Leukemia	CCLE	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation altering degron motif	0.7139
p.A1977V	ACH-000986	Colon/Colorectal Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1667
p.A1977V	HT-115	large intestine	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1667
p.W1081C	ACH-001407	Bladder Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.1667
p.G1991C	ACH-001786	Colon/Colorectal Cancer	CCLE	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1389
p.M2090I	ACH-002020	Cervical Cancer	CCLE	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.1944
p.M2090I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.1944
p.D1957H	ACH-002446	Gastric Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1667
p.R2242K	A427	lung	COSMIC	TKENR	DEG_APCC_KENBOX_2	2234:2238	Mutation rewiring degron network	0.2222
p.L1755W	SNB75	central nervous system	COSMIC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1667
p.A1477T	JHH-7	liver	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.0833
p.D1452Y	HT-115	large intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.0833
p.Q2092H	COR-L88	lung	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.1389
p.P1971L	AU565	breast	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.6471
p.H1737Y	SNU-1040	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1111
p.H1756Y	SNU-1040	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1745:1749	Mutation rewiring degron network	0.1389
p.A2004T	SNU-1040	large intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation altering degron motif	0.7139
p.D1471Y	HT-115	large intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	1461:1468	Mutation rewiring degron network	0.25
p.G1993R	IGROV-1	ovary	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1944
p.G1974R	IGROV-1	ovary	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation substituting flanking lysine	0.3611
p.T2013M	NCI-H630	large intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1111
p.L1228P	KYSE-270	oesophagus	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.7582
p.G1967D	IA-LM	lung	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.7198
p.G1967D	SUIT-2	pancreas	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.7198
p.A1608P	HCC1395	breast	COSMIC	LLTPLQS	DEG_SCF_FBW7_1	1600:1606	Mutation rewiring degron network	0.2778
p.A1235T	COLO-668	lung	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.1667
p.A1063T	COLO-668	lung	COSMIC	LKEND	DEG_APCC_KENBOX_2	1071:1075	Mutation rewiring degron network	0.1111
p.D2086G	NCI-H1299	lung	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.3056
p.A1958V	HT-115	large intestine	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1944
p.G1218E	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation rewiring degron network	0.25
p.T2008M	NCI-H630	large intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.25
p.M2071I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.1944
p.T1989M	NCI-H630	large intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.0833
p.R1226C	NCI-SNU-1	stomach	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.719
p.R1226C	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	SRGTLRHIS	DEG_APCC_DBOX_1	1221:1229	Mutation altering degron motif	0.719
p.G2087C	HAL-01	haematopoietic and lymphoid tissue	COSMIC	NNAAGYSCGP	CBL_PTK	2076:2085	Mutation rewiring degron network	0.2778
p.V1992A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	1998:2005	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTPN13

UniProt ID: Q12923

Entrez ID: 5783

Protein name: Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTPN13 in