DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: CBL_PTK

Location: 2076:2085

E3 ligase: CBL

DEGRON score: 0.5397

ASA_SCORE: 57.02

COIL: 0.7855

CONS_SCORE: 0.3176

DSS_SCORE: 0.4158

HELIX: 0.1287

FCONS_SCORE: 0.8811

RIG_SCORE: 0.6947

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2072K	TCGA-17-Z026	LUAD	TCGA	NNAAGYSCGP	CBL_PTK	0.2222
p.L2077I	TCGA-A5-A2K5	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	0.7174
p.L2077I	TCGA-EO-A3B0	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	0.7174
p.E2080K	TCGA-AX-A05Z	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	0.7022
p.E2080K	TCGA-GN-A8LK	SKCM	TCGA	NNAAGYSCGP	CBL_PTK	0.7022
p.E2080K	ACH-001569	Skin Cancer	CCLE	NNAAGYSCGP	CBL_PTK	0.7022
p.A2084S	TCGA-BS-A0TC	UCEC	TCGA	NNAAGYSCGP	CBL_PTK	0.7588
p.G2089C	TCGA-FS-A1Z0	SKCM	TCGA	NNAAGYSCGP	CBL_PTK	0.3333
p.F2086L	DO220484	KICH	ICGC	NNAAGYSCGP	CBL_PTK	0.3056
p.G2082R	DO222908	MELA	ICGC	NNAAGYSCGP	CBL_PTK	0.7568
p.Y2088D	DO43154	UCEC	ICGC	NNAAGYSCGP	CBL_PTK	0.25
p.F2086S	DO43755	UCEC	ICGC	NNAAGYSCGP	CBL_PTK	0.3056
p.M2095I	SIDM00381	Cervical Carcinoma	GDSC	NNAAGYSCGP	CBL_PTK	0.0556
p.M2095I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	0.0556
p.C2088R	SIDM00228	Thyroid Gland Carcinoma	GDSC	NNAAGYSCGP	CBL_PTK	0.25
p.C2088R	ACH-000897	Thyroid Cancer	CCLE	NNAAGYSCGP	CBL_PTK	0.25
p.M2090I	ACH-002020	Cervical Cancer	CCLE	NNAAGYSCGP	CBL_PTK	0.1944
p.M2090I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	0.1944
p.Q2092H	COR-L88	lung	COSMIC	NNAAGYSCGP	CBL_PTK	0.1389
p.D2086G	NCI-H1299	lung	COSMIC	NNAAGYSCGP	CBL_PTK	0.3056
p.M2071I	SKG-IIIa	cervix	COSMIC	NNAAGYSCGP	CBL_PTK	0.1944
p.G2087C	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	NNAAGYSCGP	CBL_PTK	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	CBL_PTK	2076:2085	NNAAGYSCGP	CBL	0.5397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons