DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_Kelch_Keap1_1

Location: 312:317

E3 ligase: KEAP1

DEGRON score: 0.8399

ASA_SCORE: 65.4167

COIL: 0.7657

CONS_SCORE: 0.3608

DSS_SCORE: 0.3061

HELIX: 0.1535

FCONS_SCORE: 0.8807

RIG_SCORE: 0.7072

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E317K	TCGA-2J-AAB6	PAAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.7022
p.E317K	DO51656	PAAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.7022
p.H325R	TCGA-AD-6889	COAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.1111
p.H325R	DO8463	COAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1111
p.P326H	TCGA-BF-A1PU	SKCM	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.0833
p.P326H	DO50278	SKCM	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.0833
p.R323H	TCGA-BR-6852	STAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.R323H	TCGA-D8-A1X9	BRCA	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.R323H	DO5472	BRCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.R323H	DO233837	GACA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.R323H	DO38202	STAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.R323H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	DFSSGE	DEG_Kelch_Keap1_1	0.1667
p.S302F	TCGA-DF-A2KU	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.S302F	TCGA-W3-AA1O	SKCM	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.S302F	DO51274	SKCM	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.S302F	DO223286	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.D310G	TCGA-EO-A22R	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.2778
p.D310G	DO42713	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.2778
p.T308I	TCGA-EY-A1GU	UCEC	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.2222
p.T308I	DO41518	UCEC	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.2222
p.H325N	TCGA-KQ-A41N	BLCA	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.1111
p.H325N	DO223588	BLCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1111
p.L305F	TCGA-VQ-A91V	STAD	TCGA	DFSSGE	DEG_Kelch_Keap1_1	0.1389
p.L305F	DO222356	STAD	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.1389
p.E327Q	DO225334	BRCA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.A319S	DO228976	LICA	ICGC	DFSSGE	DEG_Kelch_Keap1_1	0.2778
p.A319T	SIDM02050	Colorectal Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	0.2778
p.R322H	SIDM00839	Colorectal Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	0.1944
p.R322H	ACH-000950	Colon/Colorectal Cancer	CCLE	DFSSGE	DEG_Kelch_Keap1_1	0.1944
p.R322H	LoVo	large_intestine	COSMIC	DFSSGE	DEG_Kelch_Keap1_1	0.1944
p.E327K	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	DFSSGE	DEG_Kelch_Keap1_1	0.0556
p.E327K	ACH-000912	Lung Cancer	CCLE	DFSSGE	DEG_Kelch_Keap1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DFSSGE

Degron related mutations and impact score

Drug responses associated with PTPN13 mutations

All proteins holding degron of DFSSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_Kelch_Keap1_1	312:317	DFSSGE	KEAP1	0.8399	More...