DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_APCC_DBOX_1

Location: 1963:1971

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 73.8333

COIL: 0.8494

CONS_SCORE: 0.4117

DSS_SCORE: 0.4235

HELIX: 0.0189

FCONS_SCORE: 1.1514

RIG_SCORE: 0.7424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1969I	TCGA-D3-A2JO	SKCM	TCGA	TRNDLPVVP	DEG_APCC_DBOX_1	0.8102
p.P1973S	TCGA-DA-A95Z	SKCM	TCGA	TRNDLPVVP	DEG_APCC_DBOX_1	0.7222
p.D1974N	DO8634	COAD	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	0.3611
p.N1971S	DO234199	ESAD	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	0.7069
p.F1981L	DO233950	GACA	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	0.0556
p.H1972N	DO47623	SKCM	ICGC	TRNDLPVVP	DEG_APCC_DBOX_1	0.75
p.P1976L	SIDM00898	Breast Carcinoma	GDSC	TRNDLPVVP	DEG_APCC_DBOX_1	0.1944
p.P1976L	ACH-000248	Breast Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	0.1944
p.P1976L	AU565	breast	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.1944
p.A1977V	ACH-000986	Colon/Colorectal Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	0.1667
p.A1977V	HT-115	large_intestine	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.1667
p.D1957H	ACH-002446	Gastric Cancer	CCLE	TRNDLPVVP	DEG_APCC_DBOX_1	0.1667
p.P1971L	AU565	breast	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.6471
p.G1974R	IGROV-1	ovary	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.3611
p.G1967D	IA-LM	lung	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.7198
p.G1967D	SUIT-2	pancreas	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.7198
p.A1958V	HT-115	large_intestine	COSMIC	TRNDLPVVP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_DBOX_1	1963:1971	TRNDLPVVP	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons