DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_SCF_FBW7_1

Location: 1461:1468

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 82.125

COIL: 0.9218

CONS_SCORE: 0.403

DSS_SCORE: 0.6171

HELIX: 0.0235

FCONS_SCORE: 1.0768

RIG_SCORE: 0.7317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1469I	TCGA-2W-A8YY	CESC	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	0.3056
p.T1469I	DO223732	CESC	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	0.3056
p.K1456N	TCGA-FS-A1ZM	SKCM	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	0.1944
p.K1456N	DO37731	SKCM	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	0.1944
p.P1467Q	TCGA-H4-A2HO	BLCA	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	0.7035
p.P1467Q	DO494	BLCA	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	0.7035
p.P1467Q	SIDM01950	Colorectal Carcinoma	GDSC	VPVTPQCT	DEG_SCF_FBW7_1	0.7035
p.S1459C	TCGA-XF-A9SZ	BLCA	TCGA	VPVTPQCT	DEG_SCF_FBW7_1	0.2778
p.S1459C	DO51919	BLCA	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	0.2778
p.G1457R	DO229177	LMS	ICGC	VPVTPQCT	DEG_SCF_FBW7_1	0.2222
p.D1476Y	SIDM00534	Colorectal Carcinoma	GDSC	VPVTPQCT	DEG_SCF_FBW7_1	0.1111
p.D1476Y	ACH-000986	Colon/Colorectal Cancer	CCLE	VPVTPQCT	DEG_SCF_FBW7_1	0.1111
p.D1476Y	HT-115	large_intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	0.1111
p.A1477T	JHH-7	liver	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	0.0833
p.D1452Y	HT-115	large_intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	0.0833
p.D1471Y	HT-115	large_intestine	COSMIC	VPVTPQCT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SCF_FBW7_1	1461:1468	VPVTPQCT	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons