DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_SCF_FBW7_1

Location: 1998:2005

E3 ligase: FBXW7

DEGRON score: 0.9572

ASA_SCORE: 72.6625

COIL: 0.8875

CONS_SCORE: 0.3251

DSS_SCORE: 0.4554

HELIX: 0.054

FCONS_SCORE: 1.1342

RIG_SCORE: 0.6893

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1997L	TCGA-91-6848	LUAD	TCGA	PALTPNDS	DEG_SCF_FBW7_1	0.3056
p.G1998E	TCGA-CV-7250	HNSC	TCGA	PALTPNDS	DEG_SCF_FBW7_1	0.7199
p.S1994F	TCGA-D3-A8GI	SKCM	TCGA	PALTPNDS	DEG_SCF_FBW7_1	0.2222
p.G1993C	TCGA-ER-A19P	SKCM	TCGA	PALTPNDS	DEG_SCF_FBW7_1	0.1944
p.G2015C	DO10662	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.0556
p.P1997S	DO9876	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.3056
p.R2014W	DO8264	COAD	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.0833
p.V1993I	DO233791	GACA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.1944
p.V1993I	huH-1	liver	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1944
p.V2009F	DO229037	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.2222
p.A1988S	DO229045	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.0556
p.V1989L	DO229009	LICA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.0833
p.G2015S	DO37406	SKCM	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.0556
p.G2003S	DO37471	SKCM	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.6993
p.A2004D	DO40670	THCA	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.7793
p.T2002M	DO42384	UCEC	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.7423
p.T2002M	DO42568	UCEC	ICGC	PALTPNDS	DEG_SCF_FBW7_1	0.7423
p.G1991D	SIDM00371	Pancreatic Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	0.1389
p.G1991D	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	0.1389
p.G1991D	IA-LM	lung	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1389
p.G1991D	SUIT-2	pancreas	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1389
p.G1998R	SIDM00151	Ovarian Carcinoma	GDSC	PALTPNDS	DEG_SCF_FBW7_1	0.7568
p.G1998R	ACH-000966	Ovarian Cancer	CCLE	PALTPNDS	DEG_SCF_FBW7_1	0.7568
p.G1998R	IGROV-1	ovary	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.7568
p.G1991C	ACH-001786	Colon/Colorectal Cancer	CCLE	PALTPNDS	DEG_SCF_FBW7_1	0.1389
p.A2004T	SNU-1040	large_intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.7139
p.G1993R	IGROV-1	ovary	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1944
p.T2013M	NCI-H630	large_intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1111
p.T2008M	NCI-H630	large_intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.25
p.T1989M	NCI-H630	large_intestine	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.0833
p.V1992A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PALTPNDS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PALTPNDS

Degron related mutations and impact score

Drug responses associated with PTPN13 mutations

All proteins holding degron of PALTPNDS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SCF_FBW7_1	1998:2005	PALTPNDS	FBXW7	0.9572	More...