DegronMD

Uniprot ID: Q12923

Source protein: Tyrosine-protein phosphatase non-receptor type 13

Source gene: PTPN13

Class: DEG_APCC_KENBOX_2

Location: 2234:2238

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6328

ASA_SCORE: 88.28

COIL: 0.713

CONS_SCORE: 0.4672

DSS_SCORE: 0.3773

HELIX: 0.2722

FCONS_SCORE: 0.8613

RIG_SCORE: 0.7617

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C2234F	TCGA-78-7220	LUAD	TCGA	TKENR	DEG_APCC_KENBOX_2	0.7108
p.R2247G	TCGA-AJ-A3EK	UCEC	TCGA	TKENR	DEG_APCC_KENBOX_2	0.0833
p.K2245N	TCGA-CN-A63W	HNSC	TCGA	TKENR	DEG_APCC_KENBOX_2	0.1389
p.G2237W	TCGA-EE-A29X	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	0.7825
p.D2244N	DO1071	BRCA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2778
p.S2246F	DO234276	ESAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.1111
p.C2229F	DO229029	LICA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.1944
p.D2247H	DO45462	LUSC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.G2225W	DO37715	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.G2235E	DO51763	STAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.7199
p.L2241I	DO41361	UCEC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.25
p.R2247K	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.R2247K	A427	lung	COSMIC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.R2242K	A427	lung	COSMIC	TKENR	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	DEG_APCC_KENBOX_2	492:496	TKENR	APC,CDC20,FZR1	0.9841	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	2234:2238	TKENR	APC,CDC20,FZR1	0.6328	More...
Q8IZ07	Ankyrin repeat domain-containing protein 13A	DEG_APCC_KENBOX_2	68:72	TKENR	APC,CDC20,FZR1	0.723	More...
Q9BSD7	Cancer-related nucleoside-triphosphatase	DEG_APCC_KENBOX_2	170:174	TKENR	APC,CDC20,FZR1	0.7693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons