DegronMD

Uniprot ID: Q9BSD7

Source protein: Cancer-related nucleoside-triphosphatase

Source gene: NTPCR

Class: DEG_APCC_KENBOX_2

Location: 170:174

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7693

ASA_SCORE: 76.02

COIL: 0.4948

CONS_SCORE: 0.62

DSS_SCORE: 0.2634

HELIX: 0.474

FCONS_SCORE: 1.3491

RIG_SCORE: 0.7883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C184Y	TCGA-5R-AA1C	LIHC	TCGA	TKENR	DEG_APCC_KENBOX_2	0.0556
p.C184Y	DO219545	LIHC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0556
p.V166L	TCGA-94-A5I4	LUSC	TCGA	TKENR	DEG_APCC_KENBOX_2	0.2222
p.V166L	DO219175	LUSC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2222
p.D176N	DO52500	EOPC	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2778
p.Y171C	DO223145	ESCA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.7087
p.Y171C	DO229047	LICA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.7087
p.T183R	DO227516	LAML	ICGC	TKENR	DEG_APCC_KENBOX_2	0.0833
p.P179S	DO45299	LIRI	ICGC	TKENR	DEG_APCC_KENBOX_2	0.1944
p.V169I	DO229221	THCA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.3056
p.E172K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TKENR	DEG_APCC_KENBOX_2	0.7022
p.E172K	ACH-002256	Leukemia	CCLE	TKENR	DEG_APCC_KENBOX_2	0.7022
p.E172K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TKENR	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	DEG_APCC_KENBOX_2	492:496	TKENR	APC,CDC20,FZR1	0.9841	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	2234:2238	TKENR	APC,CDC20,FZR1	0.6328	More...
Q8IZ07	Ankyrin repeat domain-containing protein 13A	DEG_APCC_KENBOX_2	68:72	TKENR	APC,CDC20,FZR1	0.723	More...
Q9BSD7	Cancer-related nucleoside-triphosphatase	DEG_APCC_KENBOX_2	170:174	TKENR	APC,CDC20,FZR1	0.7693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons