DegronMD

Uniprot ID: P05060

Source protein: Secretogranin-1

Source gene: CHGB

Class: DEG_APCC_KENBOX_2

Location: 492:496

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 130.52

COIL: 0.7438

CONS_SCORE: 0.6192

DSS_SCORE: 0.675

HELIX: 0.2532

FCONS_SCORE: 1.1132

RIG_SCORE: 0.7025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F501L	TCGA-AZ-4315	COAD	TCGA	TKENR	DEG_APCC_KENBOX_2	0.1944
p.F501L	DO8842	COAD	ICGC	TKENR	DEG_APCC_KENBOX_2	0.1944
p.K482T	TCGA-BF-A5EO	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	0.1667
p.K482T	DO219450	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	0.1667
p.D488N	TCGA-DK-A6AW	BLCA	TCGA	TKENR	DEG_APCC_KENBOX_2	0.2222
p.D488N	DO48566	BLCA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2222
p.E498K	TCGA-FW-A3R5	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	0.2778
p.E498K	DO37406	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2778
p.E494D	TCGA-ND-A4WC	UCS	TCGA	TKENR	DEG_APCC_KENBOX_2	0.6758
p.R500K	DO229005	COCA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.2222
p.N495Y	DO222843	MELA	ICGC	TKENR	DEG_APCC_KENBOX_2	0.7059
p.D491H	SIDM00090	Ovarian Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	0.3056
p.D491H	ACH-000696	Ovarian Cancer	CCLE	TKENR	DEG_APCC_KENBOX_2	0.3056
p.D491H	OVCAR-8	ovary	COSMIC	TKENR	DEG_APCC_KENBOX_2	0.3056
p.T492I	SIDM01608	Endometrial Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	0.5966
p.T492I	ACH-000990	Endometrial/Uterine Cancer	CCLE	TKENR	DEG_APCC_KENBOX_2	0.5966
p.K504E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	TKENR	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	DEG_APCC_KENBOX_2	492:496	TKENR	APC,CDC20,FZR1	0.9841	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_APCC_KENBOX_2	2234:2238	TKENR	APC,CDC20,FZR1	0.6328	More...
Q8IZ07	Ankyrin repeat domain-containing protein 13A	DEG_APCC_KENBOX_2	68:72	TKENR	APC,CDC20,FZR1	0.723	More...
Q9BSD7	Cancer-related nucleoside-triphosphatase	DEG_APCC_KENBOX_2	170:174	TKENR	APC,CDC20,FZR1	0.7693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons