DegronMD - P05060(CHGB)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G240A	TCGA-13-1488	OV	TCGA	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.754
p.G240A	DO29438	OV	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.754
p.H249Q	TCGA-17-Z058	LUAD	TCGA	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1111
p.E242D	TCGA-53-A4EZ	LUAD	TCGA	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.3056
p.E242D	DO45319	LUAD	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.3056
p.E537K	TCGA-AX-A2H2	UCEC	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.E537K	TCGA-D3-A3CB	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.E537K	TCGA-YD-A9TA	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.E537K	DO47386	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.E537K	DO219503	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.E537K	DO41959	UCEC	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.F501L	TCGA-AZ-4315	COAD	TCGA	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.1944
p.F501L	DO8842	COAD	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.1944
p.K482T	TCGA-BF-A5EO	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation substituting flanking lysine	0.1667
p.K482T	DO219450	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation substituting flanking lysine	0.1667
p.H510N	TCGA-CC-5258	LIHC	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.H510N	DO22881	LIHC	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.H510Y	TCGA-D3-A51R	SKCM	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.H510Y	TCGA-FD-A3SS	BLCA	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.H510Y	DO737	BLCA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.H510Y	DO47480	SKCM	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.Q530K	TCGA-DA-A1I1	SKCM	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1111
p.Q530K	TCGA-DA-A1I1	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.25
p.Q530K	DO37966	SKCM	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1111
p.Q530K	DO37966	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.25
p.D488N	TCGA-DK-A6AW	BLCA	TCGA	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.2222
p.D488N	DO48566	BLCA	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.2222
p.G240R	TCGA-EB-A5UM	SKCM	TCGA	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7568
p.G240R	DO47282	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7568
p.G240R	SIDM00365	Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7568
p.G240R	ACH-002196	Lung Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7568
p.G240R	SBC-1	lung	COSMIC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7568
p.S533I	TCGA-EO-A3B0	UCEC	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.1667
p.S533I	DO219773	UCEC	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.1667
p.E241K	TCGA-FS-A1ZK	SKCM	TCGA	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7022
p.E241K	DO37474	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation altering degron motif	0.7022
p.E498K	TCGA-FW-A3R5	SKCM	TCGA	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.2778
p.E498K	DO37406	SKCM	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.2778
p.L529V	TCGA-IG-A3Y9	ESCA	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1389
p.L529V	TCGA-IG-A3Y9	ESCA	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.2778
p.P524S	TCGA-IH-A3EA	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation altering degron motif	0.6752
p.P524S	DO37667	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation altering degron motif	0.6752
p.E494D	TCGA-ND-A4WC	UCS	TCGA	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation altering degron motif	0.6758
p.H509N	TCGA-OR-A5KB	ACC	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1944
p.R232Q	DO222528	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2222
p.R232Q	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2222
p.E247D	DO222884	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1667
p.N248K	DO52453	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1389
p.T243A	DO229010	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	DO229013	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	DO229016	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	DO229003	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2778
p.T243A	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.2778
p.R500K	DO229005	COCA	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.2222
p.A512D	DO234257	ESAD	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2778
p.A512D	DO234257	ESAD	ICGC	FNPYYD	LIG_APCC_ABBA_1	522:527	Mutation rewiring degron network	0.0556
p.K516M	DO48316	ESCA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.6951
p.S507C	DO45095	LIRI	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1389
p.H249Y	DO222536	MELA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1111
p.E227V	DO222653	MELA	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.0833
p.S508F	DO222843	MELA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1667
p.N495Y	DO222843	MELA	ICGC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation altering degron motif	0.7059
p.E247K	DO37782	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1667
p.H509Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1944
p.D491H	SIDM00090	Ovarian Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.3056
p.D491H	ACH-000696	Ovarian Cancer	CCLE	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.3056
p.D491H	OVCAR-8	ovary	COSMIC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation rewiring degron network	0.3056
p.G519V	SIDM00819	Kidney Carcinoma	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.6421
p.G519V	ACH-002189	Kidney Cancer	CCLE	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.6421
p.G519V	RCC-FG2	kidney	COSMIC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.6421
p.H230R	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1667
p.H230R	SIDM00937	Oral Cavity Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1667
p.H230R	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.1667
p.T492I	SIDM01608	Endometrial Carcinoma	GDSC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation altering degron motif	0.5966
p.T492I	ACH-000990	Endometrial/Uterine Cancer	CCLE	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation altering degron motif	0.5966
p.K504E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	514:522	Mutation substituting flanking lysine	0.1667
p.K504E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	TKENR	DEG_APCC_KENBOX_2	492:496	Mutation substituting flanking lysine	0.2222
p.E233A	ACH-000025	Brain Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	236:241	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHGB

UniProt ID: P05060

Entrez ID: 1114

Protein name: Secretogranin-1 (Chromogranin-B) (CgB) (Secretogranin I) (SgI) [Cleaved into: PE-11; GAWK peptide; CCB peptide]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHGB in