DegronMD

Uniprot ID: P05060

Source protein: Secretogranin-1

Source gene: CHGB

Class: DEG_APCC_DBOX_1

Location: 514:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9877

ASA_SCORE: 109.8333

COIL: 0.6488

CONS_SCORE: 0.6753

DSS_SCORE: 0.4287

HELIX: 0.3007

FCONS_SCORE: 1.1036

RIG_SCORE: 0.7228

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H510N	TCGA-CC-5258	LIHC	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.H510N	DO22881	LIHC	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.H510Y	TCGA-D3-A51R	SKCM	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.H510Y	TCGA-FD-A3SS	BLCA	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.H510Y	DO737	BLCA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.H510Y	DO47480	SKCM	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.2222
p.Q530K	TCGA-DA-A1I1	SKCM	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.1111
p.Q530K	DO37966	SKCM	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.1111
p.L529V	TCGA-IG-A3Y9	ESCA	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.1389
p.H509N	TCGA-OR-A5KB	ACC	TCGA	KRKRLGELF	DEG_APCC_DBOX_1	0.1944
p.A512D	DO234257	ESAD	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.2778
p.K516M	DO48316	ESCA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.6951
p.S507C	DO45095	LIRI	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.1389
p.S508F	DO222843	MELA	ICGC	KRKRLGELF	DEG_APCC_DBOX_1	0.1667
p.H509Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	0.1944
p.G519V	SIDM00819	Kidney Carcinoma	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	0.6421
p.G519V	ACH-002189	Kidney Cancer	CCLE	KRKRLGELF	DEG_APCC_DBOX_1	0.6421
p.G519V	RCC-FG2	kidney	COSMIC	KRKRLGELF	DEG_APCC_DBOX_1	0.6421
p.K504E	SIDM01686	Chronic Myelogenous Leukemia	GDSC	KRKRLGELF	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	DEG_APCC_DBOX_1	514:522	KRKRLGELF	APC,CDC20,FZR1	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons