DegronMD

Uniprot ID: P05060

Source protein: Secretogranin-1

Source gene: CHGB

Class: LIG_APCC_ABBA_1

Location: 522:527

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9579

ASA_SCORE: 94.7667

COIL: 0.8515

CONS_SCORE: 0.6776

DSS_SCORE: 0.3257

HELIX: 0.1235

FCONS_SCORE: 1.0096

RIG_SCORE: 0.7746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E537K	TCGA-AX-A2H2	UCEC	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.E537K	TCGA-D3-A3CB	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.E537K	TCGA-YD-A9TA	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.E537K	DO47386	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.E537K	DO219503	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.E537K	DO41959	UCEC	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.0556
p.Q530K	TCGA-DA-A1I1	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.25
p.Q530K	DO37966	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.25
p.S533I	TCGA-EO-A3B0	UCEC	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.1667
p.S533I	DO219773	UCEC	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.1667
p.L529V	TCGA-IG-A3Y9	ESCA	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.2778
p.P524S	TCGA-IH-A3EA	SKCM	TCGA	FNPYYD	LIG_APCC_ABBA_1	0.6752
p.P524S	DO37667	SKCM	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.6752
p.A512D	DO234257	ESAD	ICGC	FNPYYD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	LIG_APCC_ABBA_1	522:527	FNPYYD	APC,CDC20,FZR1	0.9579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons