DegronMD

Uniprot ID: P05060

Source protein: Secretogranin-1

Source gene: CHGB

Class: DEG_Kelch_Keap1_1

Location: 236:241

E3 ligase: KEAP1

DEGRON score: 0.9781

ASA_SCORE: 98.5833

COIL: 0.8595

CONS_SCORE: 0.6043

DSS_SCORE: 0.8855

HELIX: 0.1185

FCONS_SCORE: 1.0948

RIG_SCORE: 0.458

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G240A	TCGA-13-1488	OV	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.754
p.G240A	DO29438	OV	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.754
p.H249Q	TCGA-17-Z058	LUAD	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.E242D	TCGA-53-A4EZ	LUAD	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.3056
p.E242D	DO45319	LUAD	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.3056
p.G240R	TCGA-EB-A5UM	SKCM	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.7568
p.G240R	DO47282	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.7568
p.G240R	SIDM00365	Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.7568
p.G240R	ACH-002196	Lung Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	0.7568
p.G240R	SBC-1	lung	COSMIC	SQESGE	DEG_Kelch_Keap1_1	0.7568
p.E241K	TCGA-FS-A1ZK	SKCM	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.7022
p.E241K	DO37474	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.7022
p.R232Q	DO222528	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2222
p.R232Q	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2222
p.E247D	DO222884	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.N248K	DO52453	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1389
p.T243A	DO229010	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2778
p.T243A	DO229013	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2778
p.T243A	DO229016	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2778
p.T243A	DO229003	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2778
p.T243A	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.2778
p.H249Y	DO222536	MELA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.E227V	DO222653	MELA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.0833
p.E247K	DO37782	SKCM	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.H230R	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.H230R	SIDM00937	Oral Cavity Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.H230R	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E233A	ACH-000025	Brain Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05060	Secretogranin-1	DEG_Kelch_Keap1_1	236:241	SQESGE	KEAP1	0.9781	More...
Q9UQ84	Exonuclease 1	DEG_Kelch_Keap1_1	676:681	SQESGE	KEAP1	0.8002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SQESGE

Degron related mutations and impact score

Drug responses associated with CHGB mutations

All proteins holding degron of SQESGE