DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: DEG_Kelch_Keap1_1

Location: 676:681

E3 ligase: KEAP1

DEGRON score: 0.8002

ASA_SCORE: 89.8667

COIL: 0.7998

CONS_SCORE: 0.4098

DSS_SCORE: 0.6269

HELIX: 0.1657

FCONS_SCORE: 0.907

RIG_SCORE: 0.5764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E669D	TCGA-18-3409	LUSC	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.1389
p.E669D	DO26444	LUSC	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1389
p.R668Q	TCGA-A5-A1OF	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.R668Q	DO42568	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.R668Q	SIDM00861	Ovarian Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.R668Q	ES-2	ovary	COSMIC	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.Q677R	TCGA-B5-A3FA	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.6218
p.Q677R	DO52402	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.6218
p.S673P	TCGA-EO-A22X	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.25
p.S673P	DO43907	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.25
p.A689P	TCGA-N5-A4RJ	UCS	TCGA	SQESGE	DEG_Kelch_Keap1_1	0.1111
p.E670G	DO229010	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E670G	DO229013	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E670G	DO229016	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E670G	DO229003	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E670G	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.E670G	DO228950	LICA	ICGC	SQESGE	DEG_Kelch_Keap1_1	0.1667
p.A671V	SIDM00571	Pancreatic Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	0.1944
p.A671V	ACH-000108	Pancreatic Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	0.1944
p.A671V	KP-3	pancreas	COSMIC	SQESGE	DEG_Kelch_Keap1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons