DegronMD - Q9UQ84(EXO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K444T	TCGA-10-0926	OV	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation substituting flanking lysine	0.1667
p.K444T	DO29990	OV	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation substituting flanking lysine	0.1667
p.E669D	TCGA-18-3409	LUSC	TCGA	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1389
p.E669D	DO26444	LUSC	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1389
p.H572R	TCGA-55-A4DF	LUAD	TCGA	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.2222
p.H572R	DO45318	LUAD	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.2222
p.S446I	TCGA-56-8307	LUSC	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446I	DO219139	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.T485I	TCGA-59-2372	OV	TCGA	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.T485I	DO28942	OV	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.G382C	TCGA-93-8067	LUAD	TCGA	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1111
p.G382C	TCGA-FS-A1ZJ	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1111
p.G382C	DO25113	LUAD	ICGC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1111
p.G382C	DO37956	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1111
p.R668Q	TCGA-A5-A1OF	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1111
p.R668Q	DO42568	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1111
p.R668Q	SIDM00861	Ovarian Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1111
p.R668Q	ES-2	ovary	COSMIC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1111
p.S587C	TCGA-AC-A23H	BRCA	TCGA	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1944
p.S587C	DO2401	BRCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1944
p.L390V	TCGA-AN-A04D	BRCA	TCGA	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.5654
p.L390V	DO2222	BRCA	ICGC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation altering degron motif	0.5654
p.V530I	TCGA-AO-A128	BRCA	TCGA	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2778
p.V530I	DO5326	BRCA	ICGC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2778
p.Q677R	TCGA-B5-A3FA	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation altering degron motif	0.6218
p.Q677R	DO52402	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation altering degron motif	0.6218
p.F459S	TCGA-BR-6852	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6871
p.F459S	TCGA-HU-A4H4	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6871
p.F459S	DO47721	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6871
p.F459S	DO38202	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6871
p.V464A	TCGA-BR-7707	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.3056
p.V464A	TCGA-BR-7707	STAD	TCGA	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.V464A	DO38487	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.3056
p.V464A	DO38487	STAD	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.R401L	TCGA-DA-A1HV	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1389
p.R401L	DO37659	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1389
p.T468A	TCGA-DD-AACO	LIHC	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1944
p.T468A	TCGA-DD-AACO	LIHC	TCGA	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1944
p.T468A	DO219561	LIHC	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1944
p.T468A	DO219561	LIHC	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1944
p.T383N	TCGA-EE-A20F	SKCM	TCGA	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1389
p.T383N	DO37961	SKCM	ICGC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.1389
p.S673P	TCGA-EO-A22X	UCEC	TCGA	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.25
p.S673P	DO43907	UCEC	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.25
p.V530A	TCGA-G4-6628	COAD	TCGA	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2778
p.V530A	DO10132	COAD	ICGC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2778
p.E541K	TCGA-HU-A4GN	STAD	TCGA	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1944
p.E541K	DO47833	STAD	ICGC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1944
p.T479M	TCGA-IN-A6RR	STAD	TCGA	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation altering degron motif	0.8534
p.T479M	DO230311	COCA	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation altering degron motif	0.8534
p.T479M	DO51742	STAD	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation altering degron motif	0.8534
p.A689P	TCGA-N5-A4RJ	UCS	TCGA	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1111
p.P467S	TCGA-S8-A6BV	ESCA	TCGA	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.2222
p.P467S	TCGA-S8-A6BV	ESCA	TCGA	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.D544N	DO48457	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1111
p.E670G	DO229010	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E670G	DO229013	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E670G	DO229016	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E670G	DO229003	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E670G	DO229005	COCA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E670G	DO228950	LICA	ICGC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1667
p.E589K	DO229010	COCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO229013	COCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO234285	ESAD	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO229480	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO229489	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO230659	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.E589K	DO231140	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1389
p.S456C	DO233675	GACA	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.643
p.E534D	DO229029	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.6758
p.H567R	DO23322	LINC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.0833
p.D462N	DO231104	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6932
p.G466R	DO231104	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.25
p.G466R	DO231104	LUSC	ICGC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1389
p.D571Y	DO231102	LUSC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.1944
p.D575E	DO231102	LUSC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.3056
p.S452L	DO220877	MELA	ICGC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.2778
p.E584G	DO33800	PACA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.2778
p.H572Q	DO234133	THCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	576:582	Mutation rewiring degron network	0.2222
p.P467H	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.2222
p.P467H	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.P467H	ACH-000983	Leukemia	CCLE	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.2222
p.P467H	ACH-000983	Leukemia	CCLE	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.P467H	KCL-22	haematopoietic and lymphoid tissue	COSMIC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.2222
p.P467H	KCL-22	haematopoietic and lymphoid tissue	COSMIC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.S446N	SIDM00450	Acute Myeloid Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00411	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00535	Chondrosarcoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM01199	Hepatocellular Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00367	Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00351	Oral Cavity Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00245	Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00469	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00380	Acute Myeloid Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM00008	Ovarian Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM01471	Chronic Myelogenous Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM01573	Plasma Cell Myeloma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.S446N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation rewiring degron network	0.1111
p.F483C	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.2222
p.F483C	SIDM00842	Colorectal Carcinoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.2222
p.F483C	SIDM01746	Osteosarcoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.2222
p.F483C	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.2222
p.E380Q	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0556
p.E380Q	ACH-000825	Lung Cancer	CCLE	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0556
p.E380Q	HOP-92	lung	COSMIC	LKENP	DEG_APCC_KENBOX_2	390:394	Mutation rewiring degron network	0.0556
p.A671V	SIDM00571	Pancreatic Carcinoma	GDSC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1944
p.A671V	ACH-000108	Pancreatic Cancer	CCLE	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1944
p.A671V	KP-3	pancreas	COSMIC	SQESGE	DEG_Kelch_Keap1_1	676:681	Mutation rewiring degron network	0.1944
p.Q545P	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0833
p.Q545P	ACH-000603	Lung Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0833
p.Q545P	BEN	lung	COSMIC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0833
p.A529V	SIDM00333	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.A529V	ACH-000988	Endometrial/Uterine Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.A529V	MFE-319	endometrium	COSMIC	DKENN	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.F455S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6871
p.K482T	SIDM01611	Endometrial Carcinoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation substituting flanking lysine	0.3611
p.K482T	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation substituting flanking lysine	0.3611
p.S456Y	SIDM01752	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	454:463	Mutation altering degron motif	0.6009
p.P476T	ACH-000398	Lymphoma	CCLE	VSTPPRT	DEG_SCF_FBW7_1	473:479	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EXO1

UniProt ID: Q9UQ84

Entrez ID: 9156

Protein name: Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EXO1 in