DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: DEG_SCF_FBW7_1

Location: 473:479

E3 ligase: FBXW7

DEGRON score: 0.8515

ASA_SCORE: 99.3143

COIL: 0.9499

CONS_SCORE: 0.4579

DSS_SCORE: 0.5593

HELIX: 0.027

FCONS_SCORE: 1.2289

RIG_SCORE: 0.7067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T485I	TCGA-59-2372	OV	TCGA	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.T485I	DO28942	OV	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.V464A	TCGA-BR-7707	STAD	TCGA	VSTPPRT	DEG_SCF_FBW7_1	0.0833
p.V464A	DO38487	STAD	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.0833
p.T468A	TCGA-DD-AACO	LIHC	TCGA	VSTPPRT	DEG_SCF_FBW7_1	0.1944
p.T468A	DO219561	LIHC	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.1944
p.T479M	TCGA-IN-A6RR	STAD	TCGA	VSTPPRT	DEG_SCF_FBW7_1	0.8534
p.T479M	DO230311	COCA	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.8534
p.T479M	DO51742	STAD	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.8534
p.P467S	TCGA-S8-A6BV	ESCA	TCGA	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.G466R	DO231104	LUSC	ICGC	VSTPPRT	DEG_SCF_FBW7_1	0.1389
p.P467H	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.P467H	ACH-000983	Leukemia	CCLE	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.P467H	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	VSTPPRT	DEG_SCF_FBW7_1	0.1667
p.F483C	SIDM01245	T-Lymphoblastic Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.2222
p.F483C	SIDM00842	Colorectal Carcinoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.2222
p.F483C	SIDM01746	Osteosarcoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.2222
p.F483C	SIDM00991	T-Lymphoblastic Leukemia	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.2222
p.K482T	SIDM01611	Endometrial Carcinoma	GDSC	VSTPPRT	DEG_SCF_FBW7_1	0.3611
p.K482T	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSTPPRT	DEG_SCF_FBW7_1	0.3611
p.P476T	ACH-000398	Lymphoma	CCLE	VSTPPRT	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ84	Exonuclease 1	DEG_SCF_FBW7_1	473:479	VSTPPRT	FBXW7	0.8515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons