DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: DEG_COP1_1

Location: 454:463

E3 ligase: COP1

DEGRON score: 0.8434

ASA_SCORE: 85.36

COIL: 0.7495

CONS_SCORE: 0.2154

DSS_SCORE: 0.3761

HELIX: 0.1286

FCONS_SCORE: 0.5561

RIG_SCORE: 0.7803

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K444T	TCGA-10-0926	OV	TCGA	SFSEVFVPDL	DEG_COP1_1	0.1667
p.K444T	DO29990	OV	ICGC	SFSEVFVPDL	DEG_COP1_1	0.1667
p.S446I	TCGA-56-8307	LUSC	TCGA	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446I	DO219139	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.F459S	TCGA-BR-6852	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	0.6871
p.F459S	TCGA-HU-A4H4	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	0.6871
p.F459S	DO47721	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	0.6871
p.F459S	DO38202	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	0.6871
p.V464A	TCGA-BR-7707	STAD	TCGA	SFSEVFVPDL	DEG_COP1_1	0.3056
p.V464A	DO38487	STAD	ICGC	SFSEVFVPDL	DEG_COP1_1	0.3056
p.T468A	TCGA-DD-AACO	LIHC	TCGA	SFSEVFVPDL	DEG_COP1_1	0.1944
p.T468A	DO219561	LIHC	ICGC	SFSEVFVPDL	DEG_COP1_1	0.1944
p.P467S	TCGA-S8-A6BV	ESCA	TCGA	SFSEVFVPDL	DEG_COP1_1	0.2222
p.S456C	DO233675	GACA	ICGC	SFSEVFVPDL	DEG_COP1_1	0.643
p.D462N	DO231104	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	0.6932
p.G466R	DO231104	LUSC	ICGC	SFSEVFVPDL	DEG_COP1_1	0.25
p.S452L	DO220877	MELA	ICGC	SFSEVFVPDL	DEG_COP1_1	0.2778
p.P467H	SIDM01004	Chronic Myelogenous Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	0.2222
p.P467H	ACH-000983	Leukemia	CCLE	SFSEVFVPDL	DEG_COP1_1	0.2222
p.P467H	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	SFSEVFVPDL	DEG_COP1_1	0.2222
p.S446N	SIDM00450	Acute Myeloid Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00411	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00535	Chondrosarcoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM01199	Hepatocellular Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00367	Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00351	Oral Cavity Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00245	Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00469	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00380	Acute Myeloid Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM00008	Ovarian Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM01471	Chronic Myelogenous Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM01573	Plasma Cell Myeloma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.S446N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	SFSEVFVPDL	DEG_COP1_1	0.1111
p.F455S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.6871
p.S456Y	SIDM01752	Pancreatic Carcinoma	GDSC	SFSEVFVPDL	DEG_COP1_1	0.6009

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SFSEVFVPDL

Degron related mutations and impact score

Drug responses associated with EXO1 mutations

All proteins holding degron of SFSEVFVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ84	Exonuclease 1	DEG_COP1_1	454:463	SFSEVFVPDL	COP1	0.8434	More...