DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: LIG_APCC_ABBAyCdc20_2

Location: 576:582

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9484

ASA_SCORE: 90.5571

COIL: 0.8133

CONS_SCORE: 0.4456

DSS_SCORE: 0.4872

HELIX: 0.091

FCONS_SCORE: 1.3429

RIG_SCORE: 0.7584

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H572R	TCGA-55-A4DF	LUAD	TCGA	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H572R	DO45318	LUAD	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S587C	TCGA-AC-A23H	BRCA	TCGA	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S587C	DO2401	BRCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E589K	DO229010	COCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO229013	COCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO234285	ESAD	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO229480	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO229489	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO230659	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E589K	DO231140	LAML	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.H567R	DO23322	LINC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D571Y	DO231102	LUSC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D575E	DO231102	LUSC	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E584G	DO33800	PACA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H572Q	DO234133	THCA	ICGC	KATVFTD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ84	Exonuclease 1	LIG_APCC_ABBAyCdc20_2	576:582	KATVFTD	APC,CDC20,FZR1	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons