DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DKENN
Uniprot ID:
Q9UQ84
Source protein:
Exonuclease 1
Source gene:
EXO1
Class:
DEG_APCC_KENBOX_2
Location:
532:536
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8323
ASA_SCORE:
105.88
COIL:
0.688
CONS_SCORE:
0.1606
DSS_SCORE:
0.6044
HELIX:
0.2892
FCONS_SCORE:
0.9598
RIG_SCORE:
0.7149
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V530I
TCGA-AO-A128
BRCA
TCGA
DKENN
DEG_APCC_KENBOX_2
0.2778
p.V530I
DO5326
BRCA
ICGC
DKENN
DEG_APCC_KENBOX_2
0.2778
p.V530A
TCGA-G4-6628
COAD
TCGA
DKENN
DEG_APCC_KENBOX_2
0.2778
p.V530A
DO10132
COAD
ICGC
DKENN
DEG_APCC_KENBOX_2
0.2778
p.E541K
TCGA-HU-A4GN
STAD
TCGA
DKENN
DEG_APCC_KENBOX_2
0.1944
p.E541K
DO47833
STAD
ICGC
DKENN
DEG_APCC_KENBOX_2
0.1944
p.D544N
DO48457
BLCA
ICGC
DKENN
DEG_APCC_KENBOX_2
0.1111
p.E534D
DO229029
LICA
ICGC
DKENN
DEG_APCC_KENBOX_2
0.6758
p.Q545P
SIDM00990
Non-Small Cell Lung Carcinoma
GDSC
DKENN
DEG_APCC_KENBOX_2
0.0833
p.Q545P
ACH-000603
Lung Cancer
CCLE
DKENN
DEG_APCC_KENBOX_2
0.0833
p.Q545P
BEN
lung
COSMIC
DKENN
DEG_APCC_KENBOX_2
0.0833
p.A529V
SIDM00333
Endometrial Carcinoma
GDSC
DKENN
DEG_APCC_KENBOX_2
0.25
p.A529V
ACH-000988
Endometrial/Uterine Cancer
CCLE
DKENN
DEG_APCC_KENBOX_2
0.25
p.A529V
MFE-319
endometrium
COSMIC
DKENN
DEG_APCC_KENBOX_2
0.25
Drug responses associated with EXO1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKENN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q562F6
Shugoshin 2
DEG_APCC_KENBOX_2
1114:1118
DKENN
APC,CDC20,FZR1
0.9957
More...
Q9HAW4
Claspin
DEG_APCC_KENBOX_2
696:700
DKENN
APC,CDC20,FZR1
0.9686
More...
Q9UQ84
Exonuclease 1
DEG_APCC_KENBOX_2
532:536
DKENN
APC,CDC20,FZR1
0.8323
More...
Q53SF7
Cordon-bleu protein-like 1
DEG_APCC_KENBOX_2
1040:1044
DKENN
APC,CDC20,FZR1
0.8955
More...