DegronMD

Uniprot ID: Q9UQ84

Source protein: Exonuclease 1

Source gene: EXO1

Class: DEG_APCC_KENBOX_2

Location: 532:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8323

ASA_SCORE: 105.88

COIL: 0.688

CONS_SCORE: 0.1606

DSS_SCORE: 0.6044

HELIX: 0.2892

FCONS_SCORE: 0.9598

RIG_SCORE: 0.7149

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E534D	DO229029	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.6758
p.V530I	TCGA-AO-A128	BRCA	TCGA	DKENN	DEG_APCC_KENBOX_2	0.2778
p.V530I	DO5326	BRCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.V530A	TCGA-G4-6628	COAD	TCGA	DKENN	DEG_APCC_KENBOX_2	0.2778
p.V530A	DO10132	COAD	ICGC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.A529V	SIDM00333	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.25
p.A529V	ACH-000988	Endometrial/Uterine Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.25
p.A529V	MFE-319	endometrium	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.25
p.E541K	TCGA-HU-A4GN	STAD	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1944
p.E541K	DO47833	STAD	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.D544N	DO48457	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1111
p.Q545P	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0833
p.Q545P	ACH-000603	Lung Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.0833
p.Q545P	BEN	lung	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons