DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DKENN
Uniprot ID:
Q562F6
Source protein:
Shugoshin 2
Source gene:
SGO2
Class:
DEG_APCC_KENBOX_2
Location:
1114:1118
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9957
ASA_SCORE:
106.14
COIL:
0.6066
CONS_SCORE:
0.3665
DSS_SCORE:
0.6113
HELIX:
0.372
FCONS_SCORE:
1.0755
RIG_SCORE:
0.7025
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D1114E
SIDM00982
Glioblastoma
GDSC
DKENN
DEG_APCC_KENBOX_2
0.5647
p.D1114E
42-MG-BA
central_nervous_system
COSMIC
DKENN
DEG_APCC_KENBOX_2
0.5647
Drug responses associated with SGO2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DKENN
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q562F6
Shugoshin 2
DEG_APCC_KENBOX_2
1114:1118
DKENN
APC,CDC20,FZR1
0.9957
More...
Q9HAW4
Claspin
DEG_APCC_KENBOX_2
696:700
DKENN
APC,CDC20,FZR1
0.9686
More...
Q9UQ84
Exonuclease 1
DEG_APCC_KENBOX_2
532:536
DKENN
APC,CDC20,FZR1
0.8323
More...
Q53SF7
Cordon-bleu protein-like 1
DEG_APCC_KENBOX_2
1040:1044
DKENN
APC,CDC20,FZR1
0.8955
More...