DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: DEG_APCC_KENBOX_2

Location: 696:700

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9686

ASA_SCORE: 120.98

COIL: 0.737

CONS_SCORE: 0.3352

DSS_SCORE: 0.6691

HELIX: 0.2568

FCONS_SCORE: 1.0588

RIG_SCORE: 0.6633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E686D	TCGA-AP-A0LM	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	0.0556
p.E686D	DO43306	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.G707C	TCGA-D3-A2JG	SKCM	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1389
p.G707V	TCGA-L9-A444	LUAD	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1389
p.G707V	DO26015	LUAD	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1389
p.E705Q	DO48380	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.S706R	DO229050	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1667
p.S691R	DO229006	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.G702S	SIDM00807	Bladder Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.G702S	ACH-000905	Bladder Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.2778
p.G702S	5637	urinary_tract	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.K690N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.2778
p.K697T	ACH-001347	Head and Neck Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.7306
p.D707Y	H513	pleura	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.1389
p.D696Y	H513	pleura	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.6214

DegronMD: protein-targeted degradation, mutation and drug response to degrons