DegronMD

Uniprot ID: Q53SF7

Source protein: Cordon-bleu protein-like 1

Source gene: COBLL1

Class: DEG_APCC_KENBOX_2

Location: 1040:1044

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8955

ASA_SCORE: 117.7

COIL: 0.935

CONS_SCORE: 0.4268

DSS_SCORE: 0.7087

HELIX: 0.0426

FCONS_SCORE: 0.9632

RIG_SCORE: 0.6366

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1038N	TCGA-24-2281	OV	TCGA	DKENN	DEG_APCC_KENBOX_2	0.2778
p.S1038N	DO32459	OV	ICGC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.E1043K	TCGA-AJ-A3EK	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	0.7022
p.E1043K	TCGA-FI-A2D5	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	0.7022
p.E1043K	DO41584	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	0.7022
p.E1043K	DO41331	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	0.7022
p.Q1035H	TCGA-AP-A051	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1944
p.Q1035H	TCGA-XK-AAIW	PRAD	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1944
p.Q1035H	DO51407	PRAD	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.Q1035H	DO42673	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.S1038I	TCGA-BH-A0DK	BRCA	TCGA	DKENN	DEG_APCC_KENBOX_2	0.2778
p.S1038I	DO1305	BRCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.R1041H	TCGA-BR-4184	STAD	TCGA	DKENN	DEG_APCC_KENBOX_2	0.8244
p.R1041H	DO222427	BTCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.8244
p.R1041H	DO228138	PBCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.8244
p.R1041H	DO38328	STAD	ICGC	DKENN	DEG_APCC_KENBOX_2	0.8244
p.R1041H	ACH-000048	Ovarian Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	0.8244
p.R1041H	TOV-112D	ovary	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.8244
p.A1049S	TCGA-HT-7686	LGG	TCGA	DKENN	DEG_APCC_KENBOX_2	0.1944
p.A1049S	DO22716	LGG	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1944
p.S1044L	TCGA-XF-AAMG	BLCA	TCGA	DKENN	DEG_APCC_KENBOX_2	0.7667
p.D1040H	DO219015	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.6577
p.D1040H	DO51597	CESC	ICGC	DKENN	DEG_APCC_KENBOX_2	0.6577
p.D1032E	DO229027	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	0.1111
p.F1030S	DO228853	MALY	ICGC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.E1042K	DO37531	SKCM	ICGC	DKENN	DEG_APCC_KENBOX_2	0.7022
p.N1043Y	DO51235	SKCM	ICGC	DKENN	DEG_APCC_KENBOX_2	0.7059
p.S1030F	SIDM00586	Hepatocellular Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00057	Neuroblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00552	Rhabdomyosarcoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00273	Glioblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM01695	Acute Myeloid Leukemia	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM01612	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM00165	Other Solid Cancers	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM01691	Chronic Myelogenous Leukemia	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.S1030F	SIDM01588	Endometrial Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.0556
p.K1038N	SIDM00455	Pancreatic Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.K1038N	SIDM01188	Pancreatic Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.K1038N	SIDM01101	Neuroblastoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.K1038N	SIDM00182	Head and Neck Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	0.2778
p.A1046T	CP66-MEL	skin	COSMIC	DKENN	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q562F6	Shugoshin 2	DEG_APCC_KENBOX_2	1114:1118	DKENN	APC,CDC20,FZR1	0.9957	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	696:700	DKENN	APC,CDC20,FZR1	0.9686	More...
Q9UQ84	Exonuclease 1	DEG_APCC_KENBOX_2	532:536	DKENN	APC,CDC20,FZR1	0.8323	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_KENBOX_2	1040:1044	DKENN	APC,CDC20,FZR1	0.8955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DKENN

Degron related mutations and impact score

Drug responses associated with COBLL1 mutations

All proteins holding degron of DKENN