DegronMD - Q9HAW4(CLSPN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L896F	TCGA-19-1385	GBM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.6981
p.D909G	TCGA-28-1760	GBM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.0833
p.Y887H	TCGA-44-6146	LUAD	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation blocking phosphorylation signal	0.6389
p.R102M	TCGA-A5-A1OF	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.0556
p.R102M	DO42568	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.0556
p.E686D	TCGA-AP-A0LM	UCEC	TCGA	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.0556
p.E686D	DO43306	UCEC	ICGC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.0556
p.R884M	TCGA-AP-A1DV	UCEC	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.1111
p.R884M	DO43186	UCEC	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.1111
p.L727R	TCGA-AX-A05Z	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation altering degron motif	0.8428
p.H926Y	TCGA-AX-A06F	UCEC	TCGA	KKENM	DEG_APCC_KENBOX_2	933:937	Mutation rewiring degron network	0.1389
p.R102T	TCGA-AX-A2H5	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.0556
p.R102T	DO41157	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.0556
p.S723Y	TCGA-AZ-4315	COAD	TCGA	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation blocking phosphorylation signal	0.7222
p.A24T	TCGA-B5-A0JY	UCEC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.1944
p.A24T	DO43041	UCEC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.1944
p.L92V	TCGA-B5-A1MR	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.5654
p.L92V	DO41758	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.5654
p.G736S	TCGA-B5-A3FA	UCEC	TCGA	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation rewiring degron network	0.1667
p.D25E	TCGA-BP-4964	KIRC	TCGA	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.2222
p.D25E	DO16263	KIRC	ICGC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.2222
p.N88Y	TCGA-BP-5170	KIRC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.5948
p.N88Y	DO17392	KIRC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.5948
p.E85K	TCGA-CN-4723	HNSC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.E85K	DO222427	BTCA	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.E85K	DO14830	HNSC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.E85K	SIDM00525	Osteosarcoma	GDSC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation rewiring degron network	0.25
p.G707C	TCGA-D3-A2JG	SKCM	TCGA	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1389
p.K933N	TCGA-E5-A4U1	BLCA	TCGA	KKENM	DEG_APCC_KENBOX_2	933:937	Mutation altering degron motif	0.5806
p.K933N	DO44061	BLCA	ICGC	KKENM	DEG_APCC_KENBOX_2	933:937	Mutation altering degron motif	0.5806
p.P27L	TCGA-EE-A181	SKCM	TCGA	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.2778
p.P27L	DO37444	SKCM	ICGC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.2778
p.E90D	TCGA-EO-A22X	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.6758
p.E90D	DO43907	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	88:92	Mutation altering degron motif	0.6758
p.G707V	TCGA-L9-A444	LUAD	TCGA	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1389
p.G707V	DO26015	LUAD	ICGC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1389
p.P892L	TCGA-WE-A8ZT	SKCM	TCGA	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.6471
p.P892L	DO51290	SKCM	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.6471
p.E705Q	DO48380	BLCA	ICGC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1944
p.Q728K	DO44037	BLCA	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation altering degron motif	0.6944
p.L41F	DO225215	BRCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.1389
p.L41F	DO227836	BRCA	ICGC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.1389
p.P737H	DO223703	COAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation rewiring degron network	0.1389
p.P892Q	DO8264	COAD	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5924
p.A889T	DO233840	GACA	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.25
p.P724T	DO229015	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation blocking phosphorylation signal	0.75
p.P909Q	DO229031	LICA	ICGC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.0833
p.S718Y	DO229035	LICA	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation blocking phosphorylation signal	0.5833
p.S706R	DO229050	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1667
p.S691R	DO229006	LICA	ICGC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1944
p.F937I	DO36495	READ	ICGC	KKENM	DEG_APCC_KENBOX_2	933:937	Mutation altering degron motif	0.7415
p.A739S	DO51795	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation rewiring degron network	0.0833
p.G732E	DO51761	STAD	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation rewiring degron network	0.2778
p.T923I	DO219774	UCEC	ICGC	KKENM	DEG_APCC_KENBOX_2	933:937	Mutation rewiring degron network	0.0556
p.G732V	DO41235	UCEC	ICGC	LLLFKD	LIG_APCC_ABBA_1	725:730	Mutation rewiring degron network	0.2778
p.R884S	SIDM01959	Colorectal Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation rewiring degron network	0.1111
p.P892T	SIDM01490	Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00473	Oral Cavity Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM01483	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00082	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM01017	B-Lymphoblastic Leukemia	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00631	Breast Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00414	Bladder Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM01191	Osteosarcoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM00056	Thyroid Gland Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.P892T	SIDM01743	Melanoma	GDSC	PRLPLASMD	DEG_APCC_DBOX_1	892:900	Mutation altering degron motif	0.5919
p.G702S	SIDM00807	Bladder Carcinoma	GDSC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.2778
p.G702S	ACH-000905	Bladder Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.2778
p.G702S	5637	urinary tract	COSMIC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.2778
p.I19V	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.0556
p.I19V	ACH-000937	Leukemia	CCLE	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.0556
p.I19V	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGQGS	DEG_SCF_TRCP1_1	29:34	Mutation rewiring degron network	0.0556
p.K690N	ACH-000993	Endometrial/Uterine Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation substituting flanking lysine	0.2778
p.K697T	ACH-001347	Head and Neck Cancer	CCLE	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation altering degron motif	0.7306
p.D707Y	H513	pleura	COSMIC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation rewiring degron network	0.1389
p.D696Y	H513	pleura	COSMIC	DKENN	DEG_APCC_KENBOX_2	696:700	Mutation altering degron motif	0.6214

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLSPN

UniProt ID: Q9HAW4

Entrez ID: 63967

Protein name: Claspin (hClaspin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLSPN in