DegronMD

Uniprot ID: Q9HAW4

Source protein: Claspin

Source gene: CLSPN

Class: DEG_APCC_KENBOX_2

Location: 88:92

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9937

ASA_SCORE: 107.9

COIL: 0.5156

CONS_SCORE: 0.3255

DSS_SCORE: 0.5151

HELIX: 0.467

FCONS_SCORE: 1.061

RIG_SCORE: 0.7494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R102M	TCGA-A5-A1OF	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0556
p.R102M	DO42568	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.R102T	TCGA-AX-A2H5	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0556
p.R102T	DO41157	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.L92V	TCGA-B5-A1MR	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.5654
p.L92V	DO41758	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.5654
p.N88Y	TCGA-BP-5170	KIRC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.5948
p.N88Y	DO17392	KIRC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.5948
p.E85K	TCGA-CN-4723	HNSC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.25
p.E85K	DO222427	BTCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.25
p.E85K	DO14830	HNSC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.25
p.E85K	SIDM00525	Osteosarcoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.25
p.E90D	TCGA-EO-A22X	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6758
p.E90D	DO43907	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons