DegronMD

Uniprot ID: O75113

Source protein: NEDD4-binding protein 1

Source gene: N4BP1

Class: DEG_APCC_KENBOX_2

Location: 143:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7075

ASA_SCORE: 112.2

COIL: 0.8338

CONS_SCORE: 0.4438

DSS_SCORE: 0.3498

HELIX: 0.157

FCONS_SCORE: 0.8715

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E155D	TCGA-D3-A2JC	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1111
p.E155D	DO47578	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1111
p.K144N	TCGA-DD-AAE7	LIHC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6918
p.K144N	DO52262	LIHC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6918
p.E145D	TCGA-EO-A3AV	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6758
p.E145D	DO52412	UCEC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6758
p.Q136K	DO229029	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons