DegronMD - Q96KR7(PHACTR3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R133Q	TCGA-2W-A8YY	CESC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.R133Q	TCGA-AP-A0LM	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.R133Q	TCGA-B5-A3FC	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.R133Q	TCGA-DK-A6AW	BLCA	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.R133Q	SIDM00967	Ovarian Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.R133Q	SIDM00785	Acute Myeloid Leukemia	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.T146M	TCGA-42-2591	OV	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	TCGA-D1-A1NY	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	TCGA-FI-A2F4	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	SIDM00781	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	SIDM00780	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	ACH-000967	Colon/Colorectal Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.T146M	SNU-C2B	large intestine	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.P275L	TCGA-44-2656	LUAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.7582
p.L372V	TCGA-51-6867	LUSC	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.D375H	TCGA-55-A4DF	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.A194S	TCGA-56-8307	LUSC	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2222
p.S278Y	TCGA-66-2768	LUSC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.712
p.P287H	TCGA-77-8148	LUSC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.0833
p.L288I	TCGA-78-7158	LUAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.0556
p.N369S	TCGA-85-8584	LUSC	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.A355V	TCGA-A5-A2K5	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1389
p.T354A	TCGA-AA-A00N	COAD	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.P199S	TCGA-AA-A010	COAD	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0833
p.E358Q	TCGA-AR-A256	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.D265N	TCGA-BR-8487	STAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.A175T	TCGA-CG-4460	STAD	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0556
p.V135A	TCGA-CG-5721	STAD	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.D129N	TCGA-CN-6019	HNSC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0556
p.D129N	SIDM00950	Pancreatic Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0556
p.D129N	DAN-G	pancreas	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0556
p.P132L	TCGA-CR-7402	HNSC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1389
p.K357N	TCGA-D1-A16F	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.3056
p.H176Q	TCGA-DD-AACC	LIHC	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0833
p.R286Q	TCGA-DF-A2KU	UCEC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1111
p.H285Y	TCGA-EB-A5FP	SKCM	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.E191K	TCGA-EE-A183	SKCM	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.S370F	TCGA-EE-A29L	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.G155R	TCGA-EI-6509	READ	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0556
p.R353Q	TCGA-EO-A22X	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.G155E	TCGA-FS-A1ZK	SKCM	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0556
p.G130E	TCGA-FW-A3R5	SKCM	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.S263R	TCGA-IN-A6RJ	STAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.0833
p.E360G	TCGA-MP-A4TH	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2778
p.K373N	TCGA-MP-A4TH	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.25
p.A192S	TCGA-O2-A52S	LUSC	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2778
p.Q153H	TCGA-V5-AASX	ESCA	TCGA	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1111
p.Q153H	ACH-000125	Non-Cancerous	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1111
p.L198R	TCGA-WE-A8ZM	SKCM	TCGA	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1111
p.E184K	DO51920	BLCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.A145S	DO233958	BPLL	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7588
p.A145S	NCI-H2023	lung	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7588
p.P196L	DO222955	BTCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.P196L	DO7942	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.P196L	DO46649	PAAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.F199L	DO7972	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0833
p.T356P	DO9708	COAD	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.Q186H	DO8498	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7582
p.A191D	DO8264	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.G154D	DO227996	COCA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.R352K	DO222798	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.1667
p.R370I	DO222884	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.V184M	DO52438	COCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.V184M	KNS-62	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.M142I	DO234255	ESAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7618
p.P188L	DO234194	ESAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7582
p.E149D	DO234330	ESAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.E359D	DO225448	GACA	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.25
p.R182I	DO233769	GACA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation substituting flanking lysine	0.3611
p.L372F	DO233729	GACA	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.P198S	DO14414	HNSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1111
p.T195S	DO44456	HNSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1944
p.A200T	DO17054	KIRC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0556
p.E363K	DO219688	KIRP	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7022
p.E363K	DO36881	READ	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation altering degron motif	0.7022
p.R285W	DO22281	LGG	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.R285W	DO31050	OV	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.R188M	DO229019	LICA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.8632
p.S175I	DO229022	LICA	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0556
p.G154V	DO229045	LICA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.D270N	DO48486	LIHC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.2778
p.F145L	DO52332	LIHC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.6981
p.H135Q	DO52198	LIHC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.A153T	DO231628	LINC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1111
p.Q269L	DO23858	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.25
p.K262N	DO45389	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation substituting flanking lysine	0.1667
p.D264H	DO45318	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1111
p.L177I	DO24729	LUAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1111
p.Q269K	DO23570	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.25
p.P188T	DO23557	LUAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7031
p.A273E	DO26854	LUSC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.7701
p.R370S	DO26542	LUSC	ICGC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.2222
p.S183F	DO26480	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2778
p.P176H	DO26458	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0833
p.K286N	DO26782	LUSC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1111
p.P178T	DO26671	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1389
p.A153S	DO219139	LUSC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1111
p.A151S	DO219221	LUSC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.H187Q	DO27516	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7582
p.E271K	DO229126	NKTL	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.3056
p.E271K	DO37819	SKCM	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.3056
p.A133P	DO29298	OV	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1667
p.H187Y	DO52142	PAEN	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7229
p.R285Q	DO228138	PBCA	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.R285Q	DO42793	UCEC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1389
p.S149C	DO51309	PRAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S148F	DO229491	SKCA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.25
p.E150K	DO37715	SKCM	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1944
p.P190L	DO37406	SKCM	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7582
p.E181K	DO48702	SKCM	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2222
p.R188G	DO38823	STAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.7568
p.R195C	DO38551	STAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1944
p.A134T	DO38427	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1944
p.S152R	DO51737	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1389
p.D154N	DO47867	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.R175Q	DO223286	UCEC	ICGC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0556
p.K286T	DO43755	UCEC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1111
p.A142T	DO42472	UCEC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7139
p.P154L	SIDM00608	Plasma Cell Myeloma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM01181	Hepatocellular Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM00024	Non-Cancerous	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM00989	Bladder Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM00359	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM01660	Kidney Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P154L	SIDM01574	Plasma Cell Myeloma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.0833
p.P184T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.P184T	ACH-000392	Lung Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.P184T	Calu-3	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.3056
p.K357E	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.3056
p.K357E	ACH-000521	Lung Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.3056
p.K357E	NCI-H2030	lung	COSMIC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.3056
p.L272H	SIDM00329	Hodgkin's Lymphoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.7313
p.L272H	ACH-000806	Lymphoma	CCLE	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.7313
p.L272H	L-540	haematopoietic and lymphoid tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation altering degron motif	0.7313
p.G270D	SIDM01247	Burkitt's Lymphoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.2778
p.G270D	SIDM01444	Glioblastoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.2778
p.G270D	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.2778
p.A186S	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.6477
p.A186S	ACH-000781	Lung Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.6477
p.A186S	NCI-H2023	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation altering degron motif	0.6477
p.S149L	SIDM00905	Cervical Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	ACH-001334	Cervical Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	ACH-001335	Cervical Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	ACH-002253	Lymphoma	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	C-4-I	cervix	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.S149L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.2222
p.P142L	SIDM00221	Melanoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7582
p.P142L	ACH-002388	Skin Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7582
p.S267Y	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.S267Y	ACH-000945	Lung Cancer	CCLE	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.S267Y	NCI-H650	lung	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.D179N	SIDM00943	Pancreatic Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.D179N	ACH-000107	Pancreatic Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.D179N	Capan-2	pancreas	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.A356T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.A356T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1667
p.G195D	SIDM01612	Endometrial Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1944
p.G195D	ACH-000946	Endometrial/Uterine Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1944
p.D374Y	SIDM01588	Endometrial Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.D374Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.S196R	ACH-000470	Colon/Colorectal Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.1667
p.T283K	ACH-001547	Lung Cancer	CCLE	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.T283K	ACH-001634	Leukemia	CCLE	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.P142S	ACH-001607	Gallbladder Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.6752
p.T200A	ACH-001664	Gastric Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0556
p.T282P	TT	thyroid	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.2222
p.D138N	Capan-2	pancreas	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.V284A	PF-382	haematopoietic and lymphoid tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1667
p.T279P	TT	thyroid	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.3056
p.P143T	Calu-3	lung	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7031
p.A353T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.0833
p.K354E	NCI-H2030	lung	COSMIC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation rewiring degron network	0.1111
p.S146L	JSC-1	haematopoietic and lymphoid tissue	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.S146L	C-4-I	cervix	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.3056
p.Q373R	OVMIU	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	362:366	Mutation substituting flanking lysine	0.25
p.P181T	Calu-3	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2222
p.S264Y	NCI-H650	lung	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1111
p.M150I	M14	skin	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation rewiring degron network	0.1944
p.L269H	L-540	haematopoietic and lymphoid tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.25
p.G267D	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	272:278	Mutation rewiring degron network	0.1944
p.T143M	SNU-C2B	large intestine	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	139:145	Mutation altering degron motif	0.7423
p.D176N	Capan-2	pancreas	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.0833
p.A183S	NCI-H2023	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	185:190	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHACTR3

UniProt ID: Q96KR7

Entrez ID: 116154

Protein name: Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHACTR3 in