DegronMD

Uniprot ID: Q96KR7

Source protein: Phosphatase and actin regulator 3

Source gene: PHACTR3

Class: DEG_Kelch_Keap1_1

Location: 185:190

E3 ligase: KEAP1

DEGRON score: 0.9612

ASA_SCORE: 75.7

COIL: 0.8805

CONS_SCORE: 0.3985

DSS_SCORE: 0.6395

HELIX: 0.0913

FCONS_SCORE: 0.9476

RIG_SCORE: 0.5744

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A194S	TCGA-56-8307	LUSC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.2222
p.P199S	TCGA-AA-A010	COAD	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.A175T	TCGA-CG-4460	STAD	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.H176Q	TCGA-DD-AACC	LIHC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.E191K	TCGA-EE-A183	SKCM	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.A192S	TCGA-O2-A52S	LUSC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.2778
p.L198R	TCGA-WE-A8ZM	SKCM	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.E184K	DO51920	BLCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.P196L	DO222955	BTCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.P196L	DO7942	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.P196L	DO46649	PAAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.F199L	DO7972	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.Q186H	DO8498	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7582
p.A191D	DO8264	COAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.V184M	DO52438	COCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.V184M	KNS-62	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.P188L	DO234194	ESAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7582
p.R182I	DO233769	GACA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3611
p.P198S	DO14414	HNSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.T195S	DO44456	HNSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1944
p.A200T	DO17054	KIRC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.R188M	DO229019	LICA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.8632
p.S175I	DO229022	LICA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.L177I	DO24729	LUAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.P188T	DO23557	LUAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7031
p.S183F	DO26480	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.2778
p.P176H	DO26458	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.P178T	DO26671	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1389
p.H187Q	DO27516	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7582
p.H187Y	DO52142	PAEN	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7229
p.P190L	DO37406	SKCM	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7582
p.E181K	DO48702	SKCM	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.2222
p.R188G	DO38823	STAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7568
p.R195C	DO38551	STAD	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1944
p.R175Q	DO223286	UCEC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.P184T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.P184T	ACH-000392	Lung Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.P184T	Calu-3	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.A186S	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.6477
p.A186S	ACH-000781	Lung Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.6477
p.A186S	NCI-H2023	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.6477
p.D179N	SIDM00943	Pancreatic Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.D179N	ACH-000107	Pancreatic Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.D179N	Capan-2	pancreas	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.G195D	SIDM01612	Endometrial Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.1944
p.G195D	ACH-000946	Endometrial/Uterine Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.1944
p.S196R	ACH-000470	Colon/Colorectal Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.1667
p.T200A	ACH-001664	Gastric Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.P181T	Calu-3	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.2222
p.D176N	Capan-2	pancreas	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.A183S	NCI-H2023	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDR0	TRAF3-interacting protein 1	DEG_Kelch_Keap1_1	306:311	SASSGE	KEAP1	0.9952	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_Kelch_Keap1_1	185:190	SASSGE	KEAP1	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SASSGE

Degron related mutations and impact score

Drug responses associated with PHACTR3 mutations

All proteins holding degron of SASSGE