DegronMD

Uniprot ID: Q8TDR0

Source protein: TRAF3-interacting protein 1

Source gene: TRAF3IP1

Class: DEG_Kelch_Keap1_1

Location: 306:311

E3 ligase: KEAP1

DEGRON score: 0.9952

ASA_SCORE: 81.35

COIL: 0.818

CONS_SCORE: 0.2377

DSS_SCORE: 0.6673

HELIX: 0.1593

FCONS_SCORE: 1.0205

RIG_SCORE: 0.5508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E298K	TCGA-19-5956	GBM	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.E298K	DO13863	GBM	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.E303K	TCGA-34-5928	LUSC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.25
p.E303K	DO27461	LUSC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.25
p.G310R	TCGA-AP-A1DK	UCEC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.7568
p.G310R	DO42033	UCEC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.7568
p.G319E	TCGA-AX-A2HC	UCEC	TCGA	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.G319E	DO41572	UCEC	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.1111
p.M312I	DO229024	LICA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.M312I	DO229208	THCA	ICGC	SASSGE	DEG_Kelch_Keap1_1	0.3056
p.N296T	SIDM00770	Small Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.0556
p.R297G	SIDM00927	Small Cell Lung Carcinoma	GDSC	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.R297G	ACH-000871	Lung Cancer	CCLE	SASSGE	DEG_Kelch_Keap1_1	0.0833
p.R297G	NCI-H510A	lung	COSMIC	SASSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDR0	TRAF3-interacting protein 1	DEG_Kelch_Keap1_1	306:311	SASSGE	KEAP1	0.9952	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_Kelch_Keap1_1	185:190	SASSGE	KEAP1	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons