DegronMD

Uniprot ID: Q96KR7

Source protein: Phosphatase and actin regulator 3

Source gene: PHACTR3

Class: DEG_SCF_FBW7_1

Location: 272:278

E3 ligase: FBXW7

DEGRON score: 0.9095

ASA_SCORE: 69.5

COIL: 0.893

CONS_SCORE: 0.4367

DSS_SCORE: 0.6862

HELIX: 0.0254

FCONS_SCORE: 0.9845

RIG_SCORE: 0.5504

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P275L	TCGA-44-2656	LUAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.7582
p.S278Y	TCGA-66-2768	LUSC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.712
p.P287H	TCGA-77-8148	LUSC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.0833
p.L288I	TCGA-78-7158	LUAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.0556
p.D265N	TCGA-BR-8487	STAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.R286Q	TCGA-DF-A2KU	UCEC	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.1111
p.H285Y	TCGA-EB-A5FP	SKCM	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.S263R	TCGA-IN-A6RJ	STAD	TCGA	LSTPTGS	DEG_SCF_FBW7_1	0.0833
p.R285W	DO22281	LGG	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.R285W	DO31050	OV	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.D270N	DO48486	LIHC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.2778
p.Q269L	DO23858	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.25
p.K262N	DO45389	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1667
p.D264H	DO45318	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1111
p.Q269K	DO23570	LUAD	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.25
p.A273E	DO26854	LUSC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.7701
p.K286N	DO26782	LUSC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1111
p.E271K	DO229126	NKTL	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.3056
p.E271K	DO37819	SKCM	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.3056
p.R285Q	DO228138	PBCA	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.R285Q	DO42793	UCEC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1389
p.K286T	DO43755	UCEC	ICGC	LSTPTGS	DEG_SCF_FBW7_1	0.1111
p.L272H	SIDM00329	Hodgkin's Lymphoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	0.7313
p.L272H	ACH-000806	Lymphoma	CCLE	LSTPTGS	DEG_SCF_FBW7_1	0.7313
p.L272H	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.7313
p.G270D	SIDM01247	Burkitt's Lymphoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	0.2778
p.G270D	SIDM01444	Glioblastoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	0.2778
p.G270D	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.2778
p.S267Y	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LSTPTGS	DEG_SCF_FBW7_1	0.1944
p.S267Y	ACH-000945	Lung Cancer	CCLE	LSTPTGS	DEG_SCF_FBW7_1	0.1944
p.S267Y	NCI-H650	lung	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.1944
p.T283K	ACH-001547	Lung Cancer	CCLE	LSTPTGS	DEG_SCF_FBW7_1	0.1944
p.T283K	ACH-001634	Leukemia	CCLE	LSTPTGS	DEG_SCF_FBW7_1	0.1944
p.T282P	TT	thyroid	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.2222
p.V284A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.1667
p.T279P	TT	thyroid	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.3056
p.S264Y	NCI-H650	lung	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.1111
p.L269H	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.25
p.G267D	Ramos-2G6-4C10	haematopoietic_and_lymphoid_tissue	COSMIC	LSTPTGS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSTPTGS

Degron related mutations and impact score

Drug responses associated with PHACTR3 mutations

All proteins holding degron of LSTPTGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KR7	Phosphatase and actin regulator 3	DEG_SCF_FBW7_1	272:278	LSTPTGS	FBXW7	0.9095	More...