DegronMD

Uniprot ID: Q96KR7

Source protein: Phosphatase and actin regulator 3

Source gene: PHACTR3

Class: DEG_SCF_FBW7_2

Location: 139:145

E3 ligase: FBXW7

DEGRON score: 0.6191

ASA_SCORE: 90

COIL: 0.896

CONS_SCORE: 0.4721

DSS_SCORE: 0.845

HELIX: 0.0729

FCONS_SCORE: 1.0715

RIG_SCORE: 0.5529

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R133Q	TCGA-2W-A8YY	CESC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.R133Q	TCGA-AP-A0LM	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.R133Q	TCGA-B5-A3FC	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.R133Q	TCGA-DK-A6AW	BLCA	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.R133Q	SIDM00967	Ovarian Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.R133Q	SIDM00785	Acute Myeloid Leukemia	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.T146M	TCGA-42-2591	OV	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	TCGA-D1-A1NY	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	TCGA-FI-A2F4	UCEC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	SIDM00781	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	SIDM00780	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	ACH-000967	Colon/Colorectal Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.T146M	SNU-C2B	large_intestine	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.V135A	TCGA-CG-5721	STAD	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.D129N	TCGA-CN-6019	HNSC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.0556
p.D129N	SIDM00950	Pancreatic Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0556
p.D129N	DAN-G	pancreas	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.0556
p.P132L	TCGA-CR-7402	HNSC	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1389
p.G155R	TCGA-EI-6509	READ	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.0556
p.G155E	TCGA-FS-A1ZK	SKCM	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.0556
p.G130E	TCGA-FW-A3R5	SKCM	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.Q153H	TCGA-V5-AASX	ESCA	TCGA	PPTPKSE	DEG_SCF_FBW7_2	0.1111
p.Q153H	ACH-000125	Non-Cancerous	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.1111
p.A145S	DO233958	BPLL	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.7588
p.A145S	NCI-H2023	lung	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.7588
p.G154D	DO227996	COCA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.M142I	DO234255	ESAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.7618
p.E149D	DO234330	ESAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.G154V	DO229045	LICA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.F145L	DO52332	LIHC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.6981
p.H135Q	DO52198	LIHC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.A153T	DO231628	LINC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1111
p.A153S	DO219139	LUSC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1111
p.A151S	DO219221	LUSC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.A133P	DO29298	OV	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1667
p.S149C	DO51309	PRAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S148F	DO229491	SKCA	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.25
p.E150K	DO37715	SKCM	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1944
p.A134T	DO38427	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1944
p.S152R	DO51737	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.1389
p.D154N	DO47867	STAD	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.A142T	DO42472	UCEC	ICGC	PPTPKSE	DEG_SCF_FBW7_2	0.7139
p.P154L	SIDM00608	Plasma Cell Myeloma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM01181	Hepatocellular Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM00024	Non-Cancerous	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM00989	Bladder Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM00359	Colorectal Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM01660	Kidney Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.P154L	SIDM01574	Plasma Cell Myeloma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.0833
p.S149L	SIDM00905	Cervical Carcinoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	ACH-001334	Cervical Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	ACH-001335	Cervical Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	ACH-002253	Lymphoma	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	C-4-I	cervix	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.S149L	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.2222
p.P142L	SIDM00221	Melanoma	GDSC	PPTPKSE	DEG_SCF_FBW7_2	0.7582
p.P142L	ACH-002388	Skin Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.7582
p.P142S	ACH-001607	Gallbladder Cancer	CCLE	PPTPKSE	DEG_SCF_FBW7_2	0.6752
p.D138N	Capan-2	pancreas	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.P143T	Calu-3	lung	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.7031
p.S146L	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.S146L	C-4-I	cervix	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.3056
p.M150I	M14	skin	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.1944
p.T143M	SNU-C2B	large_intestine	COSMIC	PPTPKSE	DEG_SCF_FBW7_2	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPKSE

Degron related mutations and impact score

Drug responses associated with PHACTR3 mutations

All proteins holding degron of PPTPKSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KR7	Phosphatase and actin regulator 3	DEG_SCF_FBW7_2	139:145	PPTPKSE	FBXW7	0.6191	More...