DegronMD

Uniprot ID: Q96KR7

Source protein: Phosphatase and actin regulator 3

Source gene: PHACTR3

Class: DEG_APCC_KENBOX_2

Location: 362:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9119

ASA_SCORE: 104.64

COIL: 0.6774

CONS_SCORE: 0.4962

DSS_SCORE: 0.4061

HELIX: 0.2584

FCONS_SCORE: 1.106

RIG_SCORE: 0.7598

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L372V	TCGA-51-6867	LUSC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1667
p.D375H	TCGA-55-A4DF	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0833
p.N369S	TCGA-85-8584	LUSC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.25
p.A355V	TCGA-A5-A2K5	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1389
p.T354A	TCGA-AA-A00N	COAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1111
p.E358Q	TCGA-AR-A256	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2222
p.K357N	TCGA-D1-A16F	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.3056
p.S370F	TCGA-EE-A29L	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2222
p.R353Q	TCGA-EO-A22X	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0833
p.E360G	TCGA-MP-A4TH	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2778
p.K373N	TCGA-MP-A4TH	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.25
p.T356P	DO9708	COAD	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1667
p.R352K	DO222798	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1667
p.R370I	DO222884	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2222
p.E359D	DO225448	GACA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.25
p.L372F	DO233729	GACA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1667
p.E363K	DO219688	KIRP	ICGC	NKENL	DEG_APCC_KENBOX_2	0.7022
p.E363K	DO36881	READ	ICGC	NKENL	DEG_APCC_KENBOX_2	0.7022
p.R370S	DO26542	LUSC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2222
p.K357E	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.3056
p.K357E	ACH-000521	Lung Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.3056
p.K357E	NCI-H2030	lung	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.3056
p.A356T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	NKENL	DEG_APCC_KENBOX_2	0.1667
p.A356T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.1667
p.D374Y	SIDM01588	Endometrial Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.1111
p.D374Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.1111
p.A353T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.0833
p.K354E	NCI-H2030	lung	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.1111
p.Q373R	OVMIU	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENL

Degron related mutations and impact score

Drug responses associated with PHACTR3 mutations

All proteins holding degron of NKENL