DegronMD

Uniprot ID: Q9H467

Source protein: CUE domain-containing protein 2

Source gene: CUEDC2

Class: DEG_APCC_KENBOX_2

Location: 92:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5312

ASA_SCORE: 119.1

COIL: 0.707

CONS_SCORE: 0.4562

DSS_SCORE: 0.7079

HELIX: 0.2824

FCONS_SCORE: 0.8735

RIG_SCORE: 0.6312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91S	TCGA-GV-A6ZA	BLCA	TCGA	NKENL	DEG_APCC_KENBOX_2	0.3056
p.R91S	DO49776	BLCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.3056
p.P98L	TCGA-WE-AAA0	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2778
p.P98L	DO51294	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.P98S	TCGA-WE-AAA0	SKCM	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2778
p.P98S	DO51294	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.P98Q	DO229032	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.N95K	DO27891	ORCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6918
p.D89N	SIDM00506	Small Cell Lung Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.25
p.D89N	ACH-000508	Lung Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.25
p.D89N	ACH-000975	Lung Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.25
p.D89N	COR-L88	lung	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons