DegronMD

Uniprot ID: Q8IYA6

Source protein: Cytoskeleton-associated protein 2-like

Source gene: CKAP2L

Class: DEG_APCC_KENBOX_2

Location: 184:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8788

ASA_SCORE: 108.64

COIL: 0.5682

CONS_SCORE: 0.5641

DSS_SCORE: 0.4028

HELIX: 0.3986

FCONS_SCORE: 1.4098

RIG_SCORE: 0.7768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E196Q	TCGA-95-7947	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1111
p.K185T	TCGA-A5-A0G2	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.7306
p.I191N	TCGA-AN-A0AK	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	0.25
p.N187S	TCGA-AP-A0LM	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.7069
p.E194K	TCGA-AX-A0J0	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.1667
p.E174K	TCGA-BH-A0B7	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0556
p.E174K	TCGA-BR-8680	STAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0556
p.D190N	TCGA-CA-6718	COAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.2778
p.D190N	SIDM01169	Ovarian Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.D190N	TOV-21G	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.E186D	TCGA-E6-A1LX	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6758
p.N187K	TCGA-YL-A8HO	PRAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.6918
p.Y179C	DO3686	BRCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1944
p.S193N	DO20835	KIRP	ICGC	NKENL	DEG_APCC_KENBOX_2	0.1944
p.K191N	DO45360	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	0.25
p.Q190P	DO24729	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2778
p.I197V	DO224605	LUSC	ICGC	NKENL	DEG_APCC_KENBOX_2	0.0833
p.I186F	DO48550	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	0.7415

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons